INVESTIGADORES
RODRIGUEZ Georgina Emma
artículos
Título:
Inhibition of protein synthesis and ATPase in mitochondria by the administration of the convulsant 3 mercaptopropionic acid
Autor/es:
G. RODRÍGUEZ DE LORES ARNAIZ; B. ROBIOLO DE ESTEVES; M. MISTRORIGO DE PACHECO
Revista:
LIFE SCIENCES
Editorial:
PERGAMON-ELSEVIER SCIENCE LTD
Referencias:
Año: 1975 vol. 16 p. 385 - 394
ISSN:
0024-3205
Resumen:
14C leucine incorporation into proteins by cerebral cortex subcellular fractions was studied after the administration of the convulsant 3-mercaptopropionic acid (MP). It was found that MP decreased protein synthesis by isolated nerve endings and mitochondria but not by microsomal fractions. It was also observed that mitochondrial ATPase was inhibited. These findings suggest that the inhibition of protein synthesis might be an indication of a disequilibrium of the normal energy-yielding metabolism.
