INVESTIGADORES
RODRIGUEZ Georgina Emma
artículos
Título:
Catechol O methyl-tranferase in nerve endings of rat brain
Autor/es:
M. ALBERICI; G. RODRÍGUEZ DE LORES ARNAIZ; E. DE ROBERTIS
Revista:
LIFE SCIENCES
Editorial:
PERGAMON-ELSEVIER SCIENCE LTD
Referencias:
Año: 1965 vol. 4 p. 1951 - 1960
ISSN:
0024-3205
Resumen:
AbstractThe distribution of COMT was studied in subcellular fractions of rat brain. About 50 percent of the enzyme is particulate and concentrated in the nerve ending fractions. The solubility of the enzyme after the osmotic rupture of the nerve ending makes impossible a finer localization of the enzyme within the synaptic complex. The difference in localization with MAO and the probable physiological action of the two enzymes on brain catecholamines are discussed.
