INVESTIGADORES
RODRIGUEZ Georgina Emma
artículos
Título:
5-Hydroxytryptophan- decarboxylase activity in normal and denervated pineal glands of rats
Autor/es:
A. PELLEGRINO DE IRALDI; G. RODRÍGUEZ DE LORES ARNAIZ
Revista:
LIFE SCIENCES
Editorial:
PERGAMON-ELSEVIER SCIENCE LTD
Referencias:
Año: 1964 vol. 3 p. 589 - 593
ISSN:
0024-3205
Resumen:
The 5-hydroxytryptophan decarboxylase was determined in normal and denervated pineal glands. In the experimental glands the determination was made at 2.5, 5, 10, 12 and 30 days after bilateral gangliectomy of the superior sympathetic ganglia. The results show an increase in enzyme activity in the denervated gland which may be as large as 150 per cent after 2.5 days and persists until 30 days.These results are discussed in relation with previous work (12) which showed that denervation produces a definite decrease in the synthesis of serotonin after injection of 5-hydroxytryptophan. The tentative hypothesis is postulated that the pineal nerves contain an inhibitory substance of the enzyme which disappears after denervation.
