INVESTIGADORES
RODRIGUEZ Georgina Emma
artículos
Título:
Isolation of synaptic vesicles from nerve endings of the rat brain
Autor/es:
E. DE ROBERTIS; G. RODRÍGUEZ DE LORES ARNAIZ; A. PELLEGRINO DE IRALDI
Revista:
NATURE
Editorial:
NATURE PUBLISHING GROUP
Referencias:
Año: 1962 vol. 194 p. 794 - 795
ISSN:
0028-0836
Resumen:
Letters to NatureNature 194, 794-795 (26 May 1962) | doi:10.1038/194794a0oE. DE ROBERTISoGEORGINA RODRÍGUEZ DE LORES ARNAIZoAMANDA PELLEGRINO DE IRALDIIsolation of Synaptic Vesicles from Nerve Endings of the Rat BrainE. DE ROBERTIS, GEORGINA RODRÍGUEZ DE LORES ARNAIZ & AMANDA PELLEGRINO DE IRALDIInstituto de Anatomía General y Embriología, Facultad de Ciencias Médicas, Buenos Aires.AbstractSINCE the discovery of ´synaptic vesicles´ as a specific component of synapses1,2 it was suggested that they could be associated with the storage and possibly with the synthesis of transmitter substances. This concept was supported by degeneration experiments3 and specially by the stimulation of some cholinergic terminals4, which suggested that within the ending a balance exists between the formation and release of synaptic vesicles. However, the isolation of such a sub-cellular component remained as the most direct approach to the elucidation of the physiological significance and chemical nature of these vesicles.
