INVESTIGADORES
RODRIGUEZ Georgina Emma
artículos
Título:
Nerve endings isolated from rats convulsed by methionine sulphoximine
Autor/es:
E. DE ROBERTIS; G. RODRÍGUEZ DE LORES ARNAIZ; O. SELLINGER
Revista:
NATURE
Editorial:
NATURE PUBLISHING GROUP
Referencias:
Año: 1966 p. 537 - 538
ISSN:
0028-0836
Resumen:
E. De Robertis, G. Rodríguez de Lores Arnaiz y O. Z. Sellinger (1966). Nerve endings isolated from rats convulsed by methionine sulphoximine. Nature 212: 537 538. Nerve Endings isolated from Rats convulsed by Methionine SulphoximineE. DE ROBERTIS, GEORGINA RODRIGUEZ DE LORES ARNAIZ & O. Z. SELLINGERInstituto de Anatomía General y Embriología, Facultad de Medicina, Universidad de Buenos Aires, Argentina.METHIONINE sulphoximine (MSO) is a toxic agent frequently used to produce experimental convulsions in various laboratory animals. These seizures are similar to human epilepsy, and several findings have pointed toward a possible biochemical mechanism of the convulsant1?3. Peters and Tower4 found a marked inhibition of glutamine synthesis in brain slices and a specific inhibition of glutamine synthetase has been observed5,6. In spite of these physiological and neurochemical changes, a morphological correlate for the action of MSO has not been found7.
