GENERALIZED EXCLUSION STATISTICS APPLIED TO PROTEIN ADSORPTION

RICCARDO, J.J.; PASINETTI P. M.; RICCARDO J.L.; RAMIREZ PASTOR A.J.

Córdoba

Congreso; 105 Reunión Nacional de la Asociación Física Argentina; 2020

ASOCIACIÓN FÍSICA ARGENTINA- UNIVERSIDAD NACIONAL DE CORDOBA

2020 - Resumen - RAFA - 105a Reunión de la Asociación Física ArgentinaThe problem of adsorption of proteins to solid surfaces is a very common but important eventwhich has a huge interest in many areas of researh such as medicine, pharmaceutical and analytical sciences, biotechnology, cell biology and biophysics, etc. Such systems have been studied on the basis of an interesant approach called Theoretical model of antifreeze protein-ice adsorption or Liu?s model [2]. This model intends to describe the problem of adsorption of large molecules (blocks occupying more than one adsorption center on a lattice). In our work, we propose a new model to describe this phenomena using a extension of a previous work of ours called Multiple Exclusion Statistics [1]. This new approach consists in treating the molecules as rectangles of M × N size, which once that they are adsorpted occupy a state and exclude some others according to a constant parameter of exclusion, gc. The exclusion parameter relates to molecular size and lattice geometry. The ocuppation number n (being n = θ/gc) can be represented in function of covegare θ and compared to a existing model. The comparison shows a remarkably a good agreement descrbing the behavior of the system. Adsorption isotherms for objects of different shape and size are also obtained and compared with Monte Carlo (MC) simulations, and theoretical results from the Liu?s model [see Eq. (16) in Ref. [2]]. The reaches and limitations of the theoretical models are discussed, as well as its possible application to the problem of antifreeze protein-ice adsorption [2].References[1] J. J. Riccardo, J. L. Riccardo, A. J. Ramirez-Pastor, P. M. Pasinetti, Multiple ExclusionStatistics, Phys. Rev. Lett. 123, (2019), 020602-5[2] J. Liu, Q. Li, Theoretical model of antifreeze protein-ice adsorption: Binding of large ligandsto a two-dimensional homogeneous lattice, Chem. Phys. Lett. 422, (2006), 67-71