OVARIAN AMH PRODUCTION IS TRANSIENTLY AFFECTED IN PUBERTAL AND PREPUBERTAL GIRLS WITH ACUTE LYMPHOBLASTIC LEUKAEMIA AND NON-HODGKIN LYMPHOMA RECEIVING CHEMOTHERAPY: A PROSPECTIVE, LONGITUDINAL STUDY

LOPEZ-DACAL, J.; PRADA, S.; GUTIÉRREZ, M.E.; BEDEACRRÁS, P.; ROPELATO, M.G.; ARCARI, A.; BALLERINI, M.G.; GRYNGARTEN, M.; SORIA, M.; MORÁN, L.; FERRARO, C.; FREIRE, A.V.; BERGADÁ, I.; DRELICHMAN, G.; AVERSA, L.; REY, R.; GRINSPON, R.

Congreso; Sociedad Argentina de Investigación Clínica; 2021

Introduction: Improvements in the treatment of oncological disease have increased survival, with the consequent concern about the long-term effects that childhood chemotherapy may have on ovarian function. AMH constitutes an indirect, reliable biomarker of the ovarian reserve.Aim: To evaluate small ovarian follicle status in girls and adolescents with hematologic malignancies during and after treatment. Methods: P prospective cohort study in children with Acute Lymphoblastic Leukaemia (ALL) or Non-Hodgkin lymphoma (NHL). Serum AMH was measured at diagnosis, during chemotherapy and until 3 years after treatment. Secondarily, FSH levels were analysed. Results were interpreted according to age or pubertal stage as appropriate and expressed as median (range) or percentage. Results: Twenty-three girls aged 7.3 yr (range 1-15,.7) were included; 15 were prepubertal and 8 pubertal at diagnosis. 83% were diagnosed with ALL, 32% classified as high risk, and 17% had NHL. Total follow-up was 4.7 yr (3-5.1). AMH was low (