Gonadectomy In Conditions Affecting Sex Development – A Registry-Based Cohort Study

LUCAS-HERALD, ANGELA K; BRYCE, JILLIAN; KYRIAKOU, ANDREAS; LJUBICIC, MARIE LINDHARDT; ARLT, WIEBKE; AUDÍ, LAURA; BALSAMO, ANTONIO; BARONIO, FEDERICO; BERTELLONI, SILVANO; BETTENDORF, MARKUS; BROOKE, ANTONIA; CLAAHSEN-VAN DER GRINTEN, HEDI L; DAVIES, JUSTIN; HERMANN, GLORIA; DE VRIES, LIAT; HUGHES, IEUAN A; TADOKORO-CUCCARO, RIEKO; DARENDELILER, FEYZA; POYRAZOGLU, SUKRAN; ELLAITHI, MONA; EVLIYAOGLU, OLCAY; FICA, SIMONA; STEJEREANU, LAVINIA; GAWLIK, ANETA; GLOBA, EVGENIA; ZELINSKA, NATALIYA; GURAN, TULAY; GÜVEN, AYLA; HANNEMA, SABINE; HIORT, OLAF; HOLTERHUS, P-M; IOTOVA, VIOLETA; MLADENOV, VILHELM; JAIN, VANDANA; SHARMA, RAJNI; JENNANE, FARIDA; JOHNSTON, COLIN; GUERRA-JUNIOR, GIL; KONRAD, DANIEL; GAISL, ODILE; KRONE, NILS P; KRONE, RUTH; LACHLAN, KATHERINE; LI, DEJUN; LICHIARDOPOL, CORINA; LISÁ, LIDKA; MARKOSYAN, RENATA LEVONI; MAZEN, INAS; MOHNIKE, KLAUS; NIEDZIELA, MAREK; NORDENSTROM, ANNA; REY, RODOLFO A; SKAE, MARS; TACK, LLOYD JW; TOMLINSON, JEREMY W; WEINTROB, NAOMI; COOLS, MARTINE; AHMED, S FAISAL

EUROPEAN JOURNAL OF ENDOCRINOLOGY

BIOSCIENTIFICA LTD

Lugar: Bristol; Año: 2021

0804-4643

Objectives: To determine trends in clinical practice for individuals with DSD requiring gonadectomy.Design: Retrospective cohort study.Methods: Information regarding age at gonadectomy according to diagnosis; reported sex; time of presentation to specialist center; and location of center from cases reported to the International DSD Registry and who were over 16 years old in January 2019.Results: Data regarding gonadectomy were available in 668 (88%) individuals from 44 centers. Of these, 248 (37%) (median age (range) 24 (17, 75) years) were male and 420 (63%) (median age (range) 26 (16, 86) years) were female. Gonadectomy was reported from 36 centers in 351/668 cases (53%). Females were more likely to undergo gonadectomy (n=311, p