Testicular function during adolescence in boys with type 1 diabetes mellitus (T1D): absence of hypogonadism and differences in endocrine profile at the beginning and end of puberty

ROCHA, A.; IÑÍGUEZ, G.; GODOY, C.; GAETE, X.; LÓPEZ, P.; LORETI, N.; CAMPO, S.; REY, R.; CODNER, E.

PEDIATRIC DIABETES

WILEY-BLACKWELL PUBLISHING, INC

Lugar: Londres; Año: 2014 vol. 15 p. 198 - 205

1399-543X

Aim: Conflicting results regarding testicular function in adults with type 1 diabetes (T1D) have been reported, but little is known about Leydig and Sertoli cell function during puberty in boys treated with multiple daily insulin doses. Our aim was to assess testicular function in boys with T1D. Methods: Pubertal boys with T1D (n=71) and healthy control boys (Control group; n=104) who were 10?18 years were studied. Both groups were matched by pubertal stage, age, and BMI. Total testosterone (TT), calculated free testosterone (cfT), SHBG, inhibin B, AMH, and gonadotropin levels were determined. Results: At the beginning of puberty, the T1D group had higher levels of SHBG (p=0.003) and similar androgen levels than the Control group. At the end of puberty, higher TT, and cfT were observed in T1D compared to the Control group (p