Hexachlorobenzene promotes angiogenesis in vivo, in a breast cancer model and neovasculogenesis in vitro, in the human endothelial cell line HMEC-1

CAROLINA PONTILLO; ALEJANDRO ESPAÑOL; FLORENCIA CHIAPPINI; NOELIA MIRET; CLAUDIA COCCA; LAURA ALVAREZ; DIANA KLEIMAN DE PISAREV; MARÍA ELENA SALES; ANDREA SILVANA RANDI

Edimburgo

Congreso; 50th Congress of the European Societies of Toxicology, EUROTOX 2014; 2014

Sociedad Europea de Toxicología

Hexachlorobenzene promotes angiogenesis in vivo, in a breast cancer model and neovasculogenesis in vitro, in the human endothelial cell line HMEC-1. Pontillo CA1, Español A2, Chiappini F1, Miret N1, Cocca C3, Alvarez L1, Kleiman DL de Pisarev1, Sales ME2, Randi AS1 (1) Laboratorio de Efectos Biológicos de Contaminantes Ambientales, Departamento de Bioquímica Humana, Facultad de Medicina, Universidad de Buenos Aires; (2) Laboratorio de Inmunofarmacología Tumoral, Centro de Estudios Farmacológicos y Botánicos (CEFYBO), Facultad de Medicina, Universidad de Buenos Aires; (3) Laboratorio de Radioisótopos, Departamento de Físico-Matemática, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, Argentina. Exposure to environmental pollutants may alter proangiogenic ability and promotes tumor growth. Hexachlorobenzene (HCB) is an organochlorine pesticide found in maternal milk and it is a ligand of the aryl hydrocarbon receptor (AhR). We demonstrated that HCB induces proliferation, migration and invasion in human breast cancer cells, as well as tumor growth and metastasis in vivo. Here, we examined the HCB action on breast cancer angiogenesis. We observed that HCB (3 and 30 mg/kg body weight) stimulates angiogenesis (42%,p