Role of the organophosphate chlorpyrifos as an endocrine disruptor in mammary gland

CLARA VENTURA; ANDRÉS VENTURINO; NADIA BOURGUIGNON; MARIA ROSA RAMOS NIETO; NOELIA MIRET; ANDREA SILVANA RANDI; MARIEL NÚÑEZ; CLAUDIA COCCA

Edimburgo

Congreso; 50th Congress of the European Societies of Toxicology, EUROTOX 2014,; 2014

Sociedad Europea de Toxicología

Role of the organophosphate chlorpyrifos as an endocrine disruptor in mammary gland. AUTHORS Clara Ventura; Andrés Venturino; Nadia Bourguignon; Maria Rosa Ramos Nieto; Noelia Miret; Andrea Randi; Mariel Núñez and Claudia Cocca Many of the chemicals found to be endocrine disruptors display controversy about whether low environmental doses produce harmful effects in humans. We demonstrated that the pesticide chlorpyrifos (CPF) may act as endocrine disruptor in vitro since induces estrogen receptor phosphorylation. Here, we studied the effect of CPF as an endocrine disruptor in vivo. Female Sprague Dawley rats 40 days old were exposed for 100 days to CPF 0.01 or 1 mg/Kg/day. Pituitary (LH and FSH) and steroid (estradiol, progesterone and testosterone) serum hormone levels were measured. Mammary gland and NMU-induced-mammary tumors were also analyzed. In mammary tissue, CPF (0.01 mg/Kg/day) induced expansion of the ductal network versus control (17±2vs11±1 number of ducts/field; p