INVESTIGADORES
RABINOVICH Gabriel Adrian
artículos
Título:
GLYCANS PAVE THE WAY FOR IMMUNOTHERAPY IN TRIPLE-NEGATIVE BREAST CANCER
Autor/es:
MARIANA SALATINO; M. ROMINA GIROTTI; GABRIEL RABINOVICH
Revista:
CANCER CELL
Editorial:
CELL PRESS
Referencias:
Lugar: Boston; Año: 2018 vol. 33
ISSN:
1535-6108
Resumen:
The clinical efficacy of therapies targeting the PD-1/PD-L1 pathway is still limited. In this issue of Cancer Cell, a PD-L1 glycosylation-based mechanism in triple-negative breast cancer has been identified that fosters immunosuppression by enhancing interactions with PD-1. Targeting glycosylated PD-L1 with a drug-conjugated antibody opens new avenues for treatment.
