INVESTIGADORES
RABINOVICH Gabriel Adrian
artículos
Título:
LINKING TUMOR HYPOXIA WITH VEGFR2 SIGNALING AND COMPENSATORY ANGIOGENESIS: GLYCANS MAKE THE DIFFERENCE
Autor/es:
CROCI,D0; RABINOVICH, GA
Revista:
ONCOIMMUNOLOGY
Editorial:
Landes Bioscience
Referencias:
Lugar: Paris; Año: 2014 vol. 3 p. 293801 - 293803
ISSN:
2162-4011
Resumen:
Although blocking vascular endothelial growth factor (VEGF) signaling is clinically beneficial in certain cancers, tumor regrowth in treated patients suggests that compensatory angiogenic programs may limit the efficacy of anti-VEGF treatment. We found that association of galectin-1 with complex N-glycans on VEGFR2 links tumor hypoxia to VEGFR2 signaling and preserves angiogenesis in response to VEGF blockade.
