INVESTIGADORES
RABINOVICH Gabriel Adrian
artículos
Título:
TSLPI: A NEW PIECE IN THE PUZZLE OF TUMOR-ASSOCIATED TH2-TYPE INFLAMMATION
Autor/es:
LADERACH DIEGO; PESOA SUSANA; COMPAGNO DANIEL; RABINOVICH GABRIEL
Revista:
IMMUNOTHERAPY
Editorial:
FUTURE MEDICINE LTD
Referencias:
Año: 2011 vol. 3 p. 713 - 717
ISSN:
1750-743X
Resumen:
Tumors may usurp certain mediators and signaling pathways used by normal cells to evade or shift immune responses (1). Unlocking these mechanisms may help the implementation of novel therapeutic approaches in cancer patients. Two independent studies published in the March issue of Journal of Experimental Medicine (1,2) show that thymic stromal lymphopoietin (TSLP), an IL-7-related cytokine abundant in the tumor microenvironment, instructs dendritic cells (DCs) to shift the balance toward Th2-mediated inflammatory responses that incite and sustain tumor progression.
