INVESTIGADORES
PIÑA Juliana
congresos y reuniones científicas
Título:
Co-processed excipients production for direct compression of orally disintegrating tablets
Autor/es:
GARCÍA, MAXIMILIANO; GALLO, LOREANA; ALLEMANDI, DANIEL; PALMA, SANTIAGO; PIÑA, JULIANA; BUCALÁ, VERÓNICA
Lugar:
Córdoba
Reunión:
Jornada; 1º Reunión Internacional de Ciencias Farmacéuticas; 2010
Institución organizadora:
Universidad Nacional de Córdoba
Resumen:
In this study, different co-processed excipients with flow characteristics suitable for the production of ODTs, using a single processing step (spray drying) prior to direct compression, were obtained. For this purpose, different low-cost and easy accessibility excipients available in the market were first selected: lactose monohydrate (LACT), mannitol (MAN), microcrystalline cellulose (MCC) and silicon dioxide (SiO2). A Buchi Spray Drier B-191 was used to process different aqueous solutions containing different excipients and concentrations. Powders were obtained using one, two (binary mixtures) or three (ternary mixtures) excipients. For all the cases, the solutions had 10wt% as total solid concentration and they were processed using the same spray drying operating conditions . The powders were subjected to different characterization tests: repose angle, Carr and Hausner indexes and tablets wettability and strength obtained at different compression pressures.
