Multielemental mapping and arsenic determination in organs of rats by micro-SRXRF

R.D. PÉREZ; C.A. RUBATTO BIRRI; M. RUBIO; G. BONGIOVANNI; C.A. PÉREZ

Activity Report/Brazilian Synchrotron Light Laboratory

Brazilian Synchrotron Light Laboratory

Lugar: Campinas (Brasil); Año: 2006 vol. 2005 p. 1 - 2

1518-0204

Arsenic is a naturally occurring element widely present in the environment. Inorganic arsenic exposure in humans is causally associated with development of malignancies in various tissues, including the skin, liver, urinary bladder, lung and prostate. It has been reported gastrointestinal, hematological, hepatic, renal, dermal, neurological, reproductive pathologies and other effects in humans due to ingestion of heavy doses, sub-acute poisoning or repeated exposures to low concentrations of arsenic. Several areas of Argentina have had high exposures to arsenic from naturally contaminated drinking water, particularly the eastern region of the province of Cordoba. The disease ascribed to arsenic contamination Argentina was called ?chronic endemicregional hydroarsenism? (HACRE, ?hidroarsenicismo crónico regional endémico, in spanish). Although arsenic is a recognized human carcinogen, the mechanism by which arsenic induces cancer is unknown, in large part due to the lack of an appropriate animal model. Since the effect of As may be due to its longer retention in certain tissues, information on the tissue dosimetry of the organic arsenicals after exposure to inorganic arsenic, as well as in vivo toxicology studies, are of critical importance. In this study, groups of Wistar rat received drinking water containing sodium arsenite (NaAsO2) at 0 and 55 ppm of arsenic ad libitum from days 50 to 110 after birth and then, the spatial distribution of metals was determined in brain, pancreas, kidney and liver by SR-MXRF.