Study of arsenic accumulation in rat kidney as function of nutritional treatment by SR- microXRF

PEREZ, R.D.; RUBATO BIRRI, P.N.; PEREZ, C.A.; RUBIO, M.; BONGIOVANNI, G.

Activity Report 2007/Brazilian Synchrotron Light Laboratory

Brazilian Association for Synchrotron Light Technology

Lugar: Campinas (Brasil); Año: 2008 p. 1 - 2

1518-0204

The carcinogenicity of arsenic in humans has been unambiguously demonstrated. Additionally, it is known that 2 millions of habitants of the Argentine Republic drink well water contaminated with As, which results in a disease known as Endemic Regional Chronic Hydroarsenicism. However, the animal models for inorganic arsenic carcinogenesis have been limited and development has been problematic. Interestingly, some recent reports have provided experimental evidence that arsenicinduced generation of free radicals can cause cell damage and death through activation of oxidative sensitive signalling pathways. Previous studies carried out by X-ray fluorescence spectrometry using synchrotron radiation (SR-mXRF) showed a high concentration of As in the renal cortex from chronically exposed rats. Since As induces oxidative stress in a dose-response relationship, the present study was designed to analyze the possible influence of dietary antioxidant on the As distributions in renal cortex from male Wistar rat chronically exposed to As by SR-mXRF.