Protective effect of Lactobacillus delbrueckii subsp. Lactis CIDCA 133 in a model of 5 Fluorouracil-Induced intestinal mucositis

DE JESUS, LUÍS CLÁUDIO LIMA; DRUMOND, MARIANA MARTINS; DE CARVALHO, ANDRÉ; SANTOS, SPENCER S.; MARTINS, FLAVIANO S.; FERREIRA, ÊNIO; FERNANDES, RENATA SALGADO; DE BARROS, ANDRÉ LUÍS BRANCO; DO CARMO, FILLIPE L.R.; PEREZ, PABLO F.; AZEVEDO, VASCO; MANCHA-AGRESTI, PAMELA

Journal of Functional Foods

Elsevier

Año: 2019 vol. 53 p. 197 - 207

1756-4646

Mucositis is a cytotoxic side effect caused by chemotherapy drugs, such as 5-Fluorouracil (5-FU), being a seriousclinical issue. Lactobacillus spp. could be a helpful strategy to alleviate 5-FU chemotherapy-caused intestinaldamage, due to their ability to contribute to intestinal homeostasis through improvement of microbiota balanceand immunomodulation. In this work we evaluated the effect of Lactobacillus delbrueckii subsp. lactis CIDCA 133fermented milk in 5-FU-induced experimental mucositis. Intestinal histology, permeability and biochemicalparameters showed that animals administrated with 5-FU and treated with CIDCA 133 fermented milk presentedreduced intestinal IgA secretion and lower permeability in the small bowel. We showed that this strain preservesvillus/crypt ratio, reduces the loss of goblet cells and inflammatory infiltration in ileum sections of 5-FU-treatedanimals. In conclusion, CIDCA 133 is able to prevent the intestinal mucosa damage caused by 5-FU revealing tobe a promising strategy for intestinal mucositis treatment.