Inhibition of platelet-derived growth factor (PDGF) receptor affects follicular development and ovarian proliferation, apoptosis and angiogenesis in prepubertal eCG-treated rats.

PASCUALI N, SCOTTI L, ABRAMOVICH D, IRUSTA G, DI PIETRO M, BAS D, TESONE M, PARBORELL F.

MOLECULAR AND CELLULAR ENDOCRINOLOGY.

ELSEVIER IRELAND LTD

Lugar: Amsterdam; Año: 2015

0303-7207

The platelet-derived growth factor (PDGF) system is crucial for blood vesselstability. In the present study, we evaluated whether PDGFs play a criticalintraovarian survival role in gonadotropin-dependent folliculogenesis. Weexamined the effect of intrabursal administration of a selective platelet-derivedgrowth factor receptor (PDGFR) inhibitor (AG1295) on follicular development,proliferation, apoptosis and blood vessel formation and stability in ovaries fromrats treated with equine chorionic gonadotropin (eCG). The percentages ofpreantral follicles (PAFs) and early antral follicles (EAFs) were lower inAG1295-treated ovaries than in control ovaries (p