INVESTIGADORES
PALMA Santiago Daniel
congresos y reuniones científicas
Título:
Development and Characterization of Dexamethasone-Loaded Crosslinked Hyaluronic Acid Films for Ocular Therapy
Autor/es:
CALLES JAVIER; ANTONIO LOPEZ-GARCÍA; PALMA S. D; VALLES ENRIQUE; DIEBOLD YOLANDA
Lugar:
Edinburgo
Reunión:
Congreso; 42nd Annual Meeting & Exposition of the Controlled Release Society; 2015
Institución organizadora:
Controlled Release Society
Resumen:
The aim of this work was the design and characterization of crosslinked hyaluronic acid (HA)-itaconic acid (IT) films loaded with dexamethasone (DEX) for topical therapy of flammatory ocular surface diseases. Films were chemically crosslinked with polyethyleneglycol diglycidyl ether (PEGDE); then physical and mechanical characterization by stressrain, x-ray diffraction, x-ray fluorescence spectrometry, and swelling assays was conducted.An in vitro therapeutic efficacy model was designe assess IL-6 production in an inflamed human corneal epithelial (HCE) cell line after film exposure.
