Colloidal properties of amiodarone in water at low concentration

BENEDINI LUCIANO; MESSINA PAULA; MANZO, RUBEN HILARIO; ALLEMANDI, DANIEL; PALMA, SANTIAGO; SCHULZ, ERICA; FRECHERO, MARISA; SCHULZ PABLO

JOURNAL OF COLLOID AND INTERFACE SCIENCE

ACADEMIC PRESS INC ELSEVIER SCIENCE

Año: 2009 vol. 342 p. 407 - 414

0021-9797

Amiodarone aqueous systems at concentrations C 6 3 mg/mL were studied with different techniques (conductivity, solubility, ion-selective electrodes, pH, viscosity, polarizing microscopy, computational simulation, electron microscopy and fluorescence at various temperatures. The Krafft point (TK = 70.6 C) was determined. A partial phase diagram was plotted showing the critical micelle concentration (CMC) dependence on temperature, the solubility and a transition between a coacervate and an unstable gel below TK as a function of temperature. The nature of aggregates below TK at different concentrations was determined. Micellization is an entropy-driven process which is probably caused by   strong dehydration of the amiodarone backbone on micellization. CMC, micelle aggregation number and TK given in earlier literature were misinterpreted in the original articles and are re-interpreted in this work.