INVESTIGADORES
PALMA Santiago Daniel
artículos
Título:
Hyaluronan-Itaconic Acid Glutaraldehyde Films for Biomedical Applications: Preliminary Studies
Autor/es:
CALLES JAVIER; RESIA JORGE; JUAN M. LLABOT; VALLES ENRIQUE; PALMA S. D
Revista:
Scientia Pharmaceutica
Editorial:
Austrian Pharmacists' Publishing House
Referencias:
Lugar: VIena; Año: 2015
ISSN:
0036-8709
Resumen:
New hyaluronic acid?itaconic acid films were synthesized as potential materialswith biomedical applications. In this work, we explored the homogeneous crosslinkingreactions of hyaluronic acid using glutaraldehyde in thepresence of itaconic acid and triacetin as plasticizers.Biomechanical properties were assessed in terms of stability by measuring swellingin aqueous environments, investigating wettability using contact angle tests andevaluating bioadhesive performance.The ductility of the materials was evaluated through stress-strain measurements andthe morphology was explored by scanning electron microscopy.The results show that the incorporation of itaconic acid improved most of the desirable properties, increasing adhesiveness and reducing wettability and swelling.The use of triacetin enhanced the strength, bioadhesiveness and ductility of the material.
