Comparative Dissolution Studies of Albendazole Oral Suspensions for Veterinary Use

GONZALEZ VIDAL N. L.; STARKLOFF W. J; BETANCOUR SILVIA; SUAREZ G; PALMA S

DISSOLUTION TECHNOLOGIES

DISSOLUTION TECHNOLOGIES, INC

Lugar: Hockessin, Delaware (USA); Año: 2013 vol. 20 p. 27 - 30

1521-298X

Helminth infections are a major health problem mainly in developing countries and the evidence of emerging resistance to all the major antihelminthics have been recognized in the field of animal husbandry. Albendazole (ABZ) is the most effective broad-spectrum antihelmintic agent. The biggest problem of this drug is its low aqueous solubility, which lead to an erratic availability and great intra-individual variations in the levels reached in different tissues. As with other poorly soluble compounds, the dissolution rate is likely to be contingent on formulation and may lead to differences in performance among different products available in the market. In previous studies, some drastic pharmacokinetic differences were observed between ABZ formulations (oral suspensions) of Uruguayan market. These samples were in vitro evaluated, in terms of ABZ content and dissolution profiles, as well as the effect of increasing agitation speeds on the dissolution rate. In vitro dissolution rate of formulation A was seriously affected by the agitation speed increase, and in the case of formulation B, it did not fulfill both essential quality requirements (drug content and dissolution profile). Further studies may be carried out in order to correlate the suspension quality with its therapeutic effectiveness.