Enhanced dissolution and systemic availability of albendazole formulated as solid dispersions

CASTRO, SILVINA; SANCHEZ - BRUNI S F; URBIZU LAURA; CONFALONIERI, ALEJANDRA; CEBALLOS LAURA; LANUSSE CARLOS; ALLEMANDI D.A.; PALMA SANTIAGO

PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY

TAYLOR & FRANCIS INC

Lugar: New York; Año: 2013 vol. 2 p. 434 - 442

1083-7450

Solid dispersions (SDs) containing the anthelmintic compound albendazole (ABZ) and either Pluronic 188 (P 188) or polyethylene glycol 6000 (PEG 6000) as hydrophilic carriers were formulated. Drug?polymers interactions in solid state were investigated using dierent techniques. Only a 4% of total ABZ was dissolved at 5 min post-incubation, reaching dissolution rates of 32.8% (PEG 6000) and 69.4% (P 188) in SDs. In this way, P 188 was substantially more e?cient as ABZ dissolution promoter in comparison to PEG 6000, especially at the initial stages of the dissolution processes (