INVESTIGADORES
PALMA Santiago Daniel
artículos
Título:
Effect of Ascorbic Acid based amphiphiles on human erythrocytes lipid membrane
Autor/es:
RASIA, M. L.; SPENGLES, M. I.; SANTIAGO DANIEL PALMA; LO NOSTRO, PIERANDREA; HILARIO MANZO, RUBEN; ALBERTO ALLEMANDI, DANIEL
Revista:
Clinical Hemorheology and Microcirculation
Referencias:
Año: 2007 vol. 33 p. 133 - 140
Resumen:
6-O-alkyl ascorbic acid esters (ASCn) are amphiphilic molecules that behave as
surfactants in aqueous solution. These compounds show physico-chemical and
aggregation properties that depend on the alkyl chain length, pH and temperature. It
must consider that ASCn have shown some physical and rheological properties that
suggest a potential utility as drug carriers.
The present paper aims to evaluate the effects of these surfactants on human
erythrocyte membranes.
The membrane properties studied were: osmotic resistance in hypotonic media, shape
transformation, and vesicle release at lytic concentration. According to our results, all
properties depended on the length of the hydrophobic chain and they did not evolve
monotonically.
Finally, the study of ASCn interaction with erythrocyte membrane allowed us to
postulate the crucial influence that the molecular structure exerts upon the manner in
which amphiphiles interact with biological membranes and the effects envolved in
them.