Design of novel antifungal mucoadhesive films Part II. Formulation and in vitro biopharmaceutical evaluation

MANUEL LLABOT, JUAN; SANTIAGO DANIEL PALMA; HILARIO MANZO, RUBEN; ALBERTO ALLEMANDI, DANIEL

International Journal of Pharmaceutics

Año: 2007 vol. 332 p. 263 - 268

0378-5173

This paper deals with the formulation of the mucoadhesive films containing nystatin. The design and formulation of the films was based on the mucoadhesive properties of carbomer 934P (CB) and carboxymethycellulose (NaCMC), and also on the plasticizer properties of polyethyleneglycol 400 (PEG400). A surfactant (ascorbyl palmitate, ASC16) was added to the system to aid in nystatin dispersion. Addition of these last two components produced a significant improvement in physicalmechanical properties (flexibility and strength) as well as an increase in the nystatin release rate. Xray powder diffraction (XRPD) and scanning electronic microscopy (SEM) were used to evaluate the morphological changes in the films while PEG400 and ASC16 were added to the formulations. Furthermore, the in vitro nystatin profile release was determined.in vitro nystatin profile release was determined.