Synthesis, characterization and biological properties of vanadyl(IV) complexes of diclofenac and indomethacin: an experimental and theoretical study

P.A.M. WILLIAMS; M.S. MOLINUEVO; N. B. OKULIK; A. H. JUBERT; S. ETCHEVERRY

APPLIED ORGANOMETALLIC CHEMISTRY

JOHN WILEY & SONS LTD

Lugar: LOndres; Año: 2005 vol. 19 p. 711 - 718

0268-2605

Two new vanadyl(IV) complexes with the non-steroidal antiinflammatory drugs Indomethacin and Diclofenac were synthesized and characterized by elemental analysis, electronic, diffuse reflectance and FTIR spectroscopies and thermal behavior. The structures of the oxo-vanadium(IV) complexes were obtained by carrying out ab initio calculations (B3LYP/3-21G**) owing to the difficulties of obtaining single crystals of good quality for X-ray studies. Indomethacin and Diclofenac did not cause any effect when tested on cellular proliferation in two osteoblast-cell lines in culture (MC3T3E1 and UMR106). The biological effect of the complexes depends on the cellular type and on the nature of the coordinated ligands.