31. Morphologic and functional alterations of erythroid cells induced by long term ingestion of aluminium.

DANIELA VITTORI; ACIRA NESSE; GLADYS PÉREZ ; GACIELA GARBOSSA

JOURNAL OF INORGANIC BIOCHEMISTRY

ELSEVIER SCIENCE INC

Lugar: Amsterdam; Año: 1999 vol. 76 p. 113 - 120

0162-0134

Anaemia has been associated with aluminium (Al) accumulation in plasma and /or bone tissue in patients with chronic renal insufficiency. Nevertheless, in previous works, we have foundshortened red-cell life span, increased omotic resistence and inhibition of colony-forming-unit-erythroid (CFU-E) development in Al-overloaded rats with normal renal function. To elucidate further the action of Al on in vivo erythropoiesis, Al citrate was provided to Sprague Dowley rats (n=18) in the drinking water for 8 months. The erythropoiesis impairment induced by Al may be a combined effect of direct action on circulating erythrocytes and interference with the cellular iron metabolism of the erythroid progenitors.