IFIBA   22255
INSTITUTO DE FISICA DE BUENOS AIRES
Unidad Ejecutora - UE
artículos
Título:
Computational Approaches to Developmental Patterning
Autor/es:
LUIS G. MORELLI; KOICHIRO URIU; SAÚL ARES; ANDREW C. OATES
Revista:
SCIENCE
Editorial:
AMER ASSOC ADVANCEMENT SCIENCE
Referencias:
Año: 2012 vol. 336 p. 187 - 191
ISSN:
0036-8075
Resumen:
Computational approaches are breaking new ground in understanding how embryos form. Here, we discuss recent studies that couple precise measurements in the embryo with appropriately matched modeling and computational methods to investigate classic embryonic patterning strategies. We include signaling gradients, activator-inhibitor systems, and coupled oscillators, as well as emerging paradigms such as tissue deformation. Parallel progress in theory and experiment will play an increasingly central role in deciphering developmental patterning.