INVESTIGADORES
MAYORGA Luis Segundo
artículos
Título:
Regulatory role for GTP binding proteins in endocytosis
Autor/es:
MAYORGA, L.S.; DIAZ, R; STAHL, P.D.
Revista:
SCIENCE
Editorial:
AMER ASSOC ADVANCEMENT SCIENCE
Referencias:
Año: 1989 vol. 244 p. 1475 - 1477
ISSN:
0036-8075
Resumen:
Guanosine 5´-triphosphate (GTP)-binding proteins have been implicated in the transport of newly synthesized proteins along the secretory pathway of yeast and mammalian cells. Early vesicle fusion events that follow receptor-mediated endocytosis as measured by three in vitro assays were blocked by guanosine 5´-O-(3-thiotriphosphate) and aluminum fluoride. The effect was specific for guanosine nucleotides and depended on the presence of cytosolic factors. Thus, GTP-binding proteins may also have a role in the transport of molecules along the endocytic pathway.
