INVESTIGADORES
MAYORGA Luis Segundo
artículos
Título:
Vesicle fusion following receptor mediated endocytosis requires a protein active in Golgi transport.
Autor/es:
DIAZ, R; MAYORGA, L.S.; WEIDMAN, P.J.; ROTHMAN, J.E.; STAHL, P.D.
Revista:
NATURE
Editorial:
NATURE PUBLISHING GROUP
Referencias:
Año: 1989 vol. 399 p. 398 - 400
ISSN:
0028-0836
Resumen:
In reconstitution studies N-ethylmaleimide, a sulphydryl alkylating reagent, inhibits both fusion of endocytic vesicles and vesicular transport in the Golgi apparatus. We show here that the same N-ethylmaleimide-sensitive factor that catalyses the vesicle-mediated transport within Golgi stacks is also required for endocytic vesicle fusion. Thus, it is likely that a common mechanism for vesicle fusion exists for both the secretory and endocytic pathways of eukaryotic cells.
