Antigenic and immunogenic spectrum of Foot-and-Mouth Disease vaccine strain O1 Campos against representative viruses of topotypes that circulated in Asia over the past decade

GALDO NOVO, SABRINA; MALIRAT, VIVIANA; MARADEI, EDUARDO; ESPINOZA, ANA MARIA; SMITSAART, ELIANA; PEDEMONTE, ANDREA; MATTION, NORA; BERGMANN, INGRID

VACCINE

ELSEVIER SCI LTD

Lugar: Amsterdam; Año: 2017 vol. 35 p. 2303 - 2307

0264-410X

Identifying vaccine strains to control outbreaks of foot-andmouthdisease virus that could spread to new regions is essential for contingency plans. This is the first report on the antigenic/immunogenic relationships of the South American O1/Campos vaccine strain withrepresentative isolates of the three currently active Asian type O topotypes. Virus neutralization tests using O1/Campos post-vaccination sera derived from cattle and pigs predicted for both species aceptable cross-protection, even after single vaccination, established by r1 values and by expectancy of protection using monovalent or polyvalent vaccines. The results indicate that effective oil vaccines containing the O1/Campos strain can be used against Asian isolates, expanding the scope of O1/Campos strain included in vaccine banks to control emergencies caused by Asian viruses, even on single-dose vaccination, and to cover the need of effective vaccines in Asia during systematic vaccination.