INVESTIGADORES
MARTIJENA Irene Delia
artículos
Título:
Metyrapone pretreatment prevents the behavioral and neurochemical sequelae induced by stress
Autor/es:
CALVO N, MARTIJENA ID, MOLINA VA, VOLOSIN M
Revista:
BRAIN RESEARCH
Editorial:
ELSEVIER SCIENCE BV
Referencias:
Año: 1998 p. 227 - 235
ISSN:
0006-8993
Resumen:
Abstract
In the present study, we examined the effect of metyrapone, an inhibitor of corticosterone CS. synthesis, on the behavioral and
neurochemical sequelae induced by a brief restraint session. A 15-min stress period induced an anxiogenic-like behavior on the elevated
plus-maze EPM., which was reversed with metyrapone 75 mgrkg i.p.. injected 3 h prior to the stress event. It was further demonstrated
that metyrapone pretreatment normalized the decrease in maximal chloride uptake following GABA stimulation observed in brain cortex
tissue obtained from animals exposed to both restraint and the EPM. In addition, plasma CS levels were assessed both after restraint and
following EPM exposure. Furthermore, the administration of both CS 2.5 mgrkg s.c. at a dose that mimics CS levels induced by
restraint. or dexamethasone DEXA, 1.25 mgrkg s.c. resulted in an anxiogenic response in the EPM comparable to that induced by
restraint. Taken together, all these evidence suggest that CS released in response to stress seems to be associated with functional changes
at the GABAergic supramolecular complex which could underlie the enhanced anxiety observed following the exposure to an aversive
experience. q1998 Elsevier Science B.V. All rights reserved.
restraint. Taken together, all these evidence suggest that CS released in response to stress seems to be associated with functional changes
at the GABAergic supramolecular complex which could underlie the enhanced anxiety observed following the exposure to an aversive
experience. q1998 Elsevier Science B.V. All rights reserved.
restraint. or dexamethasone DEXA, 1.25 mgrkg s.c. resulted in an anxiogenic response in the EPM comparable to that induced by
restraint. Taken together, all these evidence suggest that CS released in response to stress seems to be associated with functional changes
at the GABAergic supramolecular complex which could underlie the enhanced anxiety observed following the exposure to an aversive
experience. q1998 Elsevier Science B.V. All rights reserved.
restraint. Taken together, all these evidence suggest that CS released in response to stress seems to be associated with functional changes
at the GABAergic supramolecular complex which could underlie the enhanced anxiety observed following the exposure to an aversive
experience. q1998 Elsevier Science B.V. All rights reserved.
that metyrapone pretreatment normalized the decrease in maximal chloride uptake following GABA stimulation observed in brain cortex
tissue obtained from animals exposed to both restraint and the EPM. In addition, plasma CS levels were assessed both after restraint and
following EPM exposure. Furthermore, the administration of both CS 2.5 mgrkg s.c. at a dose that mimics CS levels induced by
restraint. or dexamethasone DEXA, 1.25 mgrkg s.c. resulted in an anxiogenic response in the EPM comparable to that induced by
restraint. Taken together, all these evidence suggest that CS released in response to stress seems to be associated with functional changes
at the GABAergic supramolecular complex which could underlie the enhanced anxiety observed following the exposure to an aversive
experience. q1998 Elsevier Science B.V. All rights reserved.
restraint. Taken together, all these evidence suggest that CS released in response to stress seems to be associated with functional changes
at the GABAergic supramolecular complex which could underlie the enhanced anxiety observed following the exposure to an aversive
experience. q1998 Elsevier Science B.V. All rights reserved.
restraint. or dexamethasone DEXA, 1.25 mgrkg s.c. resulted in an anxiogenic response in the EPM comparable to that induced by
restraint. Taken together, all these evidence suggest that CS released in response to stress seems to be associated with functional changes
at the GABAergic supramolecular complex which could underlie the enhanced anxiety observed following the exposure to an aversive
experience. q1998 Elsevier Science B.V. All rights reserved.
restraint. Taken together, all these evidence suggest that CS released in response to stress seems to be associated with functional changes
at the GABAergic supramolecular complex which could underlie the enhanced anxiety observed following the exposure to an aversive
experience. q1998 Elsevier Science B.V. All rights reserved.
neurochemical sequelae induced by a brief restraint session. A 15-min stress period induced an anxiogenic-like behavior on the elevated
plus-maze EPM., which was reversed with metyrapone 75 mgrkg i.p.. injected 3 h prior to the stress event. It was further demonstrated
that metyrapone pretreatment normalized the decrease in maximal chloride uptake following GABA stimulation observed in brain cortex
tissue obtained from animals exposed to both restraint and the EPM. In addition, plasma CS levels were assessed both after restraint and
following EPM exposure. Furthermore, the administration of both CS 2.5 mgrkg s.c. at a dose that mimics CS levels induced by
restraint. or dexamethasone DEXA, 1.25 mgrkg s.c. resulted in an anxiogenic response in the EPM comparable to that induced by
restraint. Taken together, all these evidence suggest that CS released in response to stress seems to be associated with functional changes
at the GABAergic supramolecular complex which could underlie the enhanced anxiety observed following the exposure to an aversive
experience. q1998 Elsevier Science B.V. All rights reserved.
restraint. Taken together, all these evidence suggest that CS released in response to stress seems to be associated with functional changes
at the GABAergic supramolecular complex which could underlie the enhanced anxiety observed following the exposure to an aversive
experience. q1998 Elsevier Science B.V. All rights reserved.
restraint. or dexamethasone DEXA, 1.25 mgrkg s.c. resulted in an anxiogenic response in the EPM comparable to that induced by
restraint. Taken together, all these evidence suggest that CS released in response to stress seems to be associated with functional changes
at the GABAergic supramolecular complex which could underlie the enhanced anxiety observed following the exposure to an aversive
experience. q1998 Elsevier Science B.V. All rights reserved.
restraint. Taken together, all these evidence suggest that CS released in response to stress seems to be associated with functional changes
at the GABAergic supramolecular complex which could underlie the enhanced anxiety observed following the exposure to an aversive
experience. q1998 Elsevier Science B.V. All rights reserved.
that metyrapone pretreatment normalized the decrease in maximal chloride uptake following GABA stimulation observed in brain cortex
tissue obtained from animals exposed to both restraint and the EPM. In addition, plasma CS levels were assessed both after restraint and
following EPM exposure. Furthermore, the administration of both CS 2.5 mgrkg s.c. at a dose that mimics CS levels induced by
restraint. or dexamethasone DEXA, 1.25 mgrkg s.c. resulted in an anxiogenic response in the EPM comparable to that induced by
restraint. Taken together, all these evidence suggest that CS released in response to stress seems to be associated with functional changes
at the GABAergic supramolecular complex which could underlie the enhanced anxiety observed following the exposure to an aversive
experience. q1998 Elsevier Science B.V. All rights reserved.
restraint. Taken together, all these evidence suggest that CS released in response to stress seems to be associated with functional changes
at the GABAergic supramolecular complex which could underlie the enhanced anxiety observed following the exposure to an aversive
experience. q1998 Elsevier Science B.V. All rights reserved.
restraint. or dexamethasone DEXA, 1.25 mgrkg s.c. resulted in an anxiogenic response in the EPM comparable to that induced by
restraint. Taken together, all these evidence suggest that CS released in response to stress seems to be associated with functional changes
at the GABAergic supramolecular complex which could underlie the enhanced anxiety observed following the exposure to an aversive
experience. q1998 Elsevier Science B.V. All rights reserved.
restraint. Taken together, all these evidence suggest that CS released in response to stress seems to be associated with functional changes
at the GABAergic supramolecular complex which could underlie the enhanced anxiety observed following the exposure to an aversive
experience. q1998 Elsevier Science B.V. All rights reserved.
CS. synthesis, on the behavioral and
neurochemical sequelae induced by a brief restraint session. A 15-min stress period induced an anxiogenic-like behavior on the elevated
plus-maze EPM., which was reversed with metyrapone 75 mgrkg i.p.. injected 3 h prior to the stress event. It was further demonstrated
that metyrapone pretreatment normalized the decrease in maximal chloride uptake following GABA stimulation observed in brain cortex
tissue obtained from animals exposed to both restraint and the EPM. In addition, plasma CS levels were assessed both after restraint and
following EPM exposure. Furthermore, the administration of both CS 2.5 mgrkg s.c. at a dose that mimics CS levels induced by
restraint. or dexamethasone DEXA, 1.25 mgrkg s.c. resulted in an anxiogenic response in the EPM comparable to that induced by
restraint. Taken together, all these evidence suggest that CS released in response to stress seems to be associated with functional changes
at the GABAergic supramolecular complex which could underlie the enhanced anxiety observed following the exposure to an aversive
experience. q1998 Elsevier Science B.V. All rights reserved.
restraint. Taken together, all these evidence suggest that CS released in response to stress seems to be associated with functional changes
at the GABAergic supramolecular complex which could underlie the enhanced anxiety observed following the exposure to an aversive
experience. q1998 Elsevier Science B.V. All rights reserved.
restraint. or dexamethasone DEXA, 1.25 mgrkg s.c. resulted in an anxiogenic response in the EPM comparable to that induced by
restraint. Taken together, all these evidence suggest that CS released in response to stress seems to be associated with functional changes
at the GABAergic supramolecular complex which could underlie the enhanced anxiety observed following the exposure to an aversive
experience. q1998 Elsevier Science B.V. All rights reserved.
restraint. Taken together, all these evidence suggest that CS released in response to stress seems to be associated with functional changes
at the GABAergic supramolecular complex which could underlie the enhanced anxiety observed following the exposure to an aversive
experience. q1998 Elsevier Science B.V. All rights reserved.
that metyrapone pretreatment normalized the decrease in maximal chloride uptake following GABA stimulation observed in brain cortex
tissue obtained from animals exposed to both restraint and the EPM. In addition, plasma CS levels were assessed both after restraint and
following EPM exposure. Furthermore, the administration of both CS 2.5 mgrkg s.c. at a dose that mimics CS levels induced by
restraint. or dexamethasone DEXA, 1.25 mgrkg s.c. resulted in an anxiogenic response in the EPM comparable to that induced by
restraint. Taken together, all these evidence suggest that CS released in response to stress seems to be associated with functional changes
at the GABAergic supramolecular complex which could underlie the enhanced anxiety observed following the exposure to an aversive
experience. q1998 Elsevier Science B.V. All rights reserved.
restraint. Taken together, all these evidence suggest that CS released in response to stress seems to be associated with functional changes
at the GABAergic supramolecular complex which could underlie the enhanced anxiety observed following the exposure to an aversive
experience. q1998 Elsevier Science B.V. All rights reserved.
restraint. or dexamethasone DEXA, 1.25 mgrkg s.c. resulted in an anxiogenic response in the EPM comparable to that induced by
restraint. Taken together, all these evidence suggest that CS released in response to stress seems to be associated with functional changes
at the GABAergic supramolecular complex which could underlie the enhanced anxiety observed following the exposure to an aversive
experience. q1998 Elsevier Science B.V. All rights reserved.
restraint. Taken together, all these evidence suggest that CS released in response to stress seems to be associated with functional changes
at the GABAergic supramolecular complex which could underlie the enhanced anxiety observed following the exposure to an aversive
experience. q1998 Elsevier Science B.V. All rights reserved.
EPM., which was reversed with metyrapone 75 mgrkg i.p.. injected 3 h prior to the stress event. It was further demonstrated
that metyrapone pretreatment normalized the decrease in maximal chloride uptake following GABA stimulation observed in brain cortex
tissue obtained from animals exposed to both restraint and the EPM. In addition, plasma CS levels were assessed both after restraint and
following EPM exposure. Furthermore, the administration of both CS 2.5 mgrkg s.c. at a dose that mimics CS levels induced by
restraint. or dexamethasone DEXA, 1.25 mgrkg s.c. resulted in an anxiogenic response in the EPM comparable to that induced by
restraint. Taken together, all these evidence suggest that CS released in response to stress seems to be associated with functional changes
at the GABAergic supramolecular complex which could underlie the enhanced anxiety observed following the exposure to an aversive
experience. q1998 Elsevier Science B.V. All rights reserved.
restraint. Taken together, all these evidence suggest that CS released in response to stress seems to be associated with functional changes
at the GABAergic supramolecular complex which could underlie the enhanced anxiety observed following the exposure to an aversive
experience. q1998 Elsevier Science B.V. All rights reserved.
restraint. or dexamethasone DEXA, 1.25 mgrkg s.c. resulted in an anxiogenic response in the EPM comparable to that induced by
restraint. Taken together, all these evidence suggest that CS released in response to stress seems to be associated with functional changes
at the GABAergic supramolecular complex which could underlie the enhanced anxiety observed following the exposure to an aversive
experience. q1998 Elsevier Science B.V. All rights reserved.
restraint. Taken together, all these evidence suggest that CS released in response to stress seems to be associated with functional changes
at the GABAergic supramolecular complex which could underlie the enhanced anxiety observed following the exposure to an aversive
experience. q1998 Elsevier Science B.V. All rights reserved.
2.5 mgrkg s.c. at a dose that mimics CS levels induced by
restraint. or dexamethasone DEXA, 1.25 mgrkg s.c. resulted in an anxiogenic response in the EPM comparable to that induced by
restraint. Taken together, all these evidence suggest that CS released in response to stress seems to be associated with functional changes
at the GABAergic supramolecular complex which could underlie the enhanced anxiety observed following the exposure to an aversive
experience. q1998 Elsevier Science B.V. All rights reserved.
restraint. Taken together, all these evidence suggest that CS released in response to stress seems to be associated with functional changes
at the GABAergic supramolecular complex which could underlie the enhanced anxiety observed following the exposure to an aversive
experience. q1998 Elsevier Science B.V. All rights reserved.
. or dexamethasone DEXA, 1.25 mgrkg s.c. resulted in an anxiogenic response in the EPM comparable to that induced by
restraint. Taken together, all these evidence suggest that CS released in response to stress seems to be associated with functional changes
at the GABAergic supramolecular complex which could underlie the enhanced anxiety observed following the exposure to an aversive
experience. q1998 Elsevier Science B.V. All rights reserved.q1998 Elsevier Science B.V. All rights reserved.