INVESTIGADORES
LOPEZ CAMELO Jorge Santiago
artículos
Título:
Agregados geográficos, condición socioeconómica y prevalencia de anomalías congénitas en Argentina
Autor/es:
PAWLUK M; CAMPAÑA H; LOPEZ CAMELO JS
Revista:
BAG. Journal of basic and applied genetics
Editorial:
Sociedad de Genetica
Referencias:
Año: 2010 vol. 21 p. 1 - 1
ISSN:
1852-6233
Resumen:
The objetive was the analysis
of the prevalence of ten congenital defects in geographic clusters (GC) in
Argentina. A sample of 16,606 newborn with congenital anomalies and their
control pairs was selected out of 39 maternities belonging to the ECLAMC
network, ascertained from 577.844 births in 25 Argentine counties between 1991
and 2001. In order to identify the GC, the NBI -unsatisfi ed basic needs- level
(2001 Census) was used as a socioeconomic indicator for each county to which the
hospital belongs. Ten congenital defects were chosen due to their clinical and
biological importance. In order to estimate the Prevalence Rate Ratio for each
GC in relation to the frequency of the anomaly observed for GC rest, a Poisson
regression analysis was used, adjusted by different hospitals from the same
cluster. Four GC were identifi ed: three unfavourable regions with high NBI
level (Bariloche, Futaleufú: 20,6%, Gran Buenos Aires: 18,6% and Noroeste:
18,4%), and a favourable region with low NBI level (Ciudad Autónoma de Buenos
Aires, 7,8% ). The fi fth GC corresponded to hospitals not included in the GC
defi ned by the program. The fi ve GC were grouped into three: High NBI
percentage (GC1, unfavourable cluster), low NBI (GC2, favourable cluster) and
all the rest (GC3). A high frequency of cleft lip with cleft palate was observed
for GC1, while esophageal atresia and hydronephrosis frequencies were low. Spina
bifi da and congenital heart defect showed higher frequencies for GC2.