INVESTIGADORES
LOPEZ CAMELO Jorge Santiago
artículos
Título:
Sentinel phenotype for rubella embryopathy: time-space distribution in Brazil.
Autor/es:
ORIOLI IM; CAMELO JS; RITTLER M; CASTILLA EE
Revista:
CADERNOS DE SAúDE PúBLICA
Editorial:
CADERNOS SAUDE PUBLICA
Referencias:
Año: 2011 vol. 27 p. 1961 - 1968
ISSN:
0102-311X
Resumen:
The dyad comprising eye anomalies and congenital heart defects in the
same newborn has been proposed as the best sentinel phenotype for the
early detection of rubella embryopathy. Time-space birth prevalence
distributions of the eye-heart dyad were described in 36 Brazilian
hospitals from the Latin-American Collaborative Study of Congenital
Anomalies - ECLAMC network, for the period 1994-2008. Seventy dyad cases
observed among 554,531 births showed seasonal variation (Χ2 = 5.84; p
< 0.05), suggesting an environmental etiology, with an increase in
cases in October-March and acrophase in December. The secular
distribution of dyad prevalence rates was consistent with the
distribution of rubella cases in Brazil, showing a decrease from 1994 to
2004, followed by an increase until 2008. Two geographic clusters were
identified, one with high and the other with low dyad prevalence. In the
high prevalence cluster, a secular increase was observed, starting in
1999, matching the rubella epidemic waves observed in Brazil in
1998-2000 and 2006.