INVESTIGADORES
LOPEZ CAMELO Jorge Santiago
artículos
Título:
Characterization of Ancestral and Derived Y-Chromosome Haplotypes of New-World Native Populations
Autor/es:
BIANCHI, NO; CATANESI, CI; BAILLIET, G; MARTINEZ-MARIGNAC, VL; BRAVI, CM; VIDAL-RIOJA, LB; HERRERA, RJ; LOPEZ-CAMELO, JS; JORGE SANTIAGO LOPEZ CAMELO
Revista:
AMERICAN JOURNAL OF HUMAN GENETICS
Editorial:
CELL PRESS
Referencias:
Año: 1998 vol. 63 p. 1862 - 1871
ISSN:
0002-9297
Resumen:
We analyze the allelic polymorphisms in seven Y-specific
microsatellite loci and a Y-specific alphoid system with
27 variants (ah IXXVII), in a total of 89 Y chromosomes
carrying the DYS199T allele and belonging to
populations representing Amerindian and Na-Dene linguistic
groups. Since there are no indications of recurrence
for the DYS199CrT transition, it is assumed that
all DYS199T haplotypes derive from a single individual
in whom the CrT mutation occurred for the first time.
We identified both the ancestral founder haplotype, 0A,
of the DYS199T lineage and seven derived haplogroups
diverging from the ancestral one by one to seven mutational
steps. The 0A haplotype (5.7% of Native American
chromosomes) had the following constitution:
DYS199T, ah II, DYS19/13, DYS389a/10, DYS389b/
27, DYS390/24, DYS391/10, DYS392/14, and
DYS393/13 (microsatellite alleles are indicated as number
of repeats). We analyzed the Y-specific microsatellite
mutation rate in 1,743 father-son transmissions, and we
pooled our data with data in the literature, to obtain an
average mutation rate of .0012. We estimated that the
0A haplotype has an average age of 22,770 years (minimum
13,500 years, maximum 58,700 years). Since the
DYS199T allele is found with high frequency in Native
American chromosomes, we propose that 0A is one of
the most prevalent founder paternal lineages of New
World aborigines.ah IXXVII), in a total of 89 Y chromosomes
carrying the DYS199T allele and belonging to
populations representing Amerindian and Na-Dene linguistic
groups. Since there are no indications of recurrence
for the DYS199CrT transition, it is assumed that
all DYS199T haplotypes derive from a single individual
in whom the CrT mutation occurred for the first time.
We identified both the ancestral founder haplotype, 0A,
of the DYS199T lineage and seven derived haplogroups
diverging from the ancestral one by one to seven mutational
steps. The 0A haplotype (5.7% of Native American
chromosomes) had the following constitution:
DYS199T, ah II, DYS19/13, DYS389a/10, DYS389b/
27, DYS390/24, DYS391/10, DYS392/14, and
DYS393/13 (microsatellite alleles are indicated as number
of repeats). We analyzed the Y-specific microsatellite
mutation rate in 1,743 father-son transmissions, and we
pooled our data with data in the literature, to obtain an
average mutation rate of .0012. We estimated that the
0A haplotype has an average age of 22,770 years (minimum
13,500 years, maximum 58,700 years). Since the
DYS199T allele is found with high frequency in Native
American chromosomes, we propose that 0A is one of
the most prevalent founder paternal lineages of New
World aborigines.rT transition, it is assumed that
all DYS199T haplotypes derive from a single individual
in whom the CrT mutation occurred for the first time.
We identified both the ancestral founder haplotype, 0A,
of the DYS199T lineage and seven derived haplogroups
diverging from the ancestral one by one to seven mutational
steps. The 0A haplotype (5.7% of Native American
chromosomes) had the following constitution:
DYS199T, ah II, DYS19/13, DYS389a/10, DYS389b/
27, DYS390/24, DYS391/10, DYS392/14, and
DYS393/13 (microsatellite alleles are indicated as number
of repeats). We analyzed the Y-specific microsatellite
mutation rate in 1,743 father-son transmissions, and we
pooled our data with data in the literature, to obtain an
average mutation rate of .0012. We estimated that the
0A haplotype has an average age of 22,770 years (minimum
13,500 years, maximum 58,700 years). Since the
DYS199T allele is found with high frequency in Native
American chromosomes, we propose that 0A is one of
the most prevalent founder paternal lineages of New
World aborigines.rT mutation occurred for the first time.
We identified both the ancestral founder haplotype, 0A,
of the DYS199T lineage and seven derived haplogroups
diverging from the ancestral one by one to seven mutational
steps. The 0A haplotype (5.7% of Native American
chromosomes) had the following constitution:
DYS199T, ah II, DYS19/13, DYS389a/10, DYS389b/
27, DYS390/24, DYS391/10, DYS392/14, and
DYS393/13 (microsatellite alleles are indicated as number
of repeats). We analyzed the Y-specific microsatellite
mutation rate in 1,743 father-son transmissions, and we
pooled our data with data in the literature, to obtain an
average mutation rate of .0012. We estimated that the
0A haplotype has an average age of 22,770 years (minimum
13,500 years, maximum 58,700 years). Since the
DYS199T allele is found with high frequency in Native
American chromosomes, we propose that 0A is one of
the most prevalent founder paternal lineages of New
World aborigines.ah II, DYS19/13, DYS389a/10, DYS389b/
27, DYS390/24, DYS391/10, DYS392/14, and
DYS393/13 (microsatellite alleles are indicated as number
of repeats). We analyzed the Y-specific microsatellite
mutation rate in 1,743 father-son transmissions, and we
pooled our data with data in the literature, to obtain an
average mutation rate of .0012. We estimated that the
0A haplotype has an average age of 22,770 years (minimum
13,500 years, maximum 58,700 years). Since the
DYS199T allele is found with high frequency in Native
American chromosomes, we propose that 0A is one of
the most prevalent founder paternal lineages of New
World aborigines.