Personalizing Precision Oncology Clinical Trials in Latin America: An Expert Panel on Challenges and Opportunities

ARAI, ROBERTO JUN; GUINDALINI, RODRIGO SANTA CRUZ; LLERA, ANDREA SABINA; O'CONNOR, JUAN MANOEL; MULLER, BETTINA; LEMA, MAURICIO; FREITAS, HELANO C.; SORIA, TANNIA; DELGADO, LUCÍA; LANDAVERDE, DENIS; MONTENEGRO, PAOLA; RIECHELMANN, RACHEL P.

THE ONCOLOGIST.

ALPHAMED PRESS

Año: 2019 vol. 24

1083-7159

The participation of patients in precision oncology trials needsto fulfill molecular-based selection criteria. This strongly limitsaccrual, and as a consequence, screening successes have decreased,costs have increased, and fewer subjects are enrolled.To achieve narrowed targets, studies have been forced to bemulticenter and multinational to reach a larger pool of candidates.However, this globalization faces many challenges, as, forexample, in the case of precision oncology trials. These trialshave a complex structure that is dependent upon a high-techinfrastructure and knowledge in a dynamic environment.Given the movement of precision clinical cancer research toregions other than Europe and the U.S., it is important toevaluate the feasibility of performing such trials in lower-middle-and low-income countries. Here we critically discussthe advantages of conducting precision oncology clinicaltrials in Latin America and make suggestions on how toovercome the main challenges involved.