Nutritional stress in eukaryotic cells: Oxidative species and regulation of survival in time of scarceness

FERRETTI AC; LAROCCA MC; FAVRE C

MOLECULAR GENETICS AND METABOLISM

ACADEMIC PRESS INC ELSEVIER SCIENCE

Año: 2012 vol. 105 p. 186 - 192

1096-7192

The survival response to glucose limitation in eukaryotic cells involves different signaling pathways highly 2323 conserved from yeasts to mammals. Upon nutritional restriction, a network driven by kinases such as the 2424 AMP dependent protein kinase (AMPK/Snf1), the Target of Rapamycin kinase (TOR), the Protein kinases A 2525 (PKA) or B (PKB/Akt) control stress defenses, cell cycle regulators, pro and anti apoptotic proteins, respiratory 2626 complexes, etc. In this work we review the state of the art in this scenario of kinase pathways, i.e. their prin- 2727 cipal effectors and links, both in yeasts and mammals. We also focus in downstream actors such as sirtuins 2828 and the Forkhead box class O transcription factors. Besides, we particularly analyze the participation of 29Forkhead box class O transcription factors. Besides, we particularly analyze the participation of 29 these kinases on the balance of Reactive Oxygen Species and their role in the regulation of survival during 3030 glucose deprivation. Key results on yeast stationary phase survival and the contribution of such genetics stud- 3131 ies are discussed.