. Human pancreatic carcinoma cell line PANC-1 and the role of histamine in growth regulation

CRICCO G; MARTIN G; LABOMBARDA F; COCCA C; BERGOC R; RIVERA E

INFLAMMATION RESEARCH

BIRKHAUSER VERLAG AG

Año: 2000 vol. 19 p. 68 - 69

1023-3830

The presence of histamine (Hi) receptors has been demonstratedin different cell lines and human neoplasias and manystudies have suggested that Hi can regulate cell growth via H1and H2 receptors [1, 2]. We have demonstrated in an experimentalmammary carcinoma that Hi is produced by tumorcells and exerts its action as an autocrine growth factorthrough H1 and H2 membrane receptors [3]. In this work weinvestigated the metabolic signalling pathways coupled to H1and H2 histamine receptors in the human cell line, Panc-I andthe possible role of histamine in the regulation of cell growth.