TRISTETRAPROLIN (TTP) EXPRESSION IS REQUIRED FOR MAINTENANCE OF THE MAMMARY PROGENITOR CELL POPULATION

MICAELA STEDILE; INES BECKERMAN; M. VICTORIA GODDIO; LOURDES PEREZ CUERVO; MARTÍN GARCÍA SOLÁ; MARÍA VICTORIA MEDINA; ANA RAIMONDI; OMAR A. COSO; EDITH C KORDON

Congreso; Reunión Anual SAIC 2019; 2019

Messenger RNA (mRNA) stability is regulated mainly by proteins that bind sequences enriched in adenine and uracil in their 3´untranslated regions, called AU-binding proteins (AUBPs). Tristetraprolin (TTP) is an AUBP that promotes mRNA degradation of proteins involved in inflammation, proliferation and tumor invasiveness. In particular, RNA-seq data indicates that TTP is up-regulated in mammary progenitor cells (p