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Evaluation of the mutagenicity of antimicrobial compound isolated from Zuccagnia punctata Cav and Amaicha del Valle propolis.
- ZAMPINI I.C., NIEVA MORENO M.I:, ORDOÑEZ R.M., VATTUONE M.A., ISLA M.I.
Congreso; XXI Jornadas de la Asociación de Biología de Tucumán; 2004
Asociación de Biología de Tucumán
Propolis is a natural resinous hive product collected by honey bees from buds of different plants. Propolis was found to have many biological properties (antibacterial, antifungal, antioxidant, antiHIV, antiinflammatory effects). In a previous work we demonstrated that the Amaicha del Valle propolis had similar chemical composition with Zuccagnia punctata Cav. From these extracts we isolated a bioactive compound which was identified as 2,4 dihydroxychalcone. The aim of this work was to evaluate mutagenicity of propolis and Z. punctata extracts and the antimicrobial compounds (2,4 dihydroxychalcone). The mutagenic effect was analyzed using Salmonella typhimurium TA98 and TA100 with and without S9 mixture. The toxicity towards S. typhimurium TA98 and TA100 was also assayed. The extracts and the antibiotic compound showed MR (mutagenicity relation) values below 2. These results indicate that the samples assayed not exhibit mutagenicity nor toxicity effects against S. typhimurium TA98 and TA100 with and without S9. Our results suggest that the extracts and the bioactive compound may be used in terapeuticals formulations as antimicrobial.