INVESTIGADORES
GRANADOS Alejandro Manuel
artículos
Título:
α-amination reaction of different ketones mediated by carbohydrate Cu2+ complexes
Autor/es:
ROSSI, LAURA I.; KRAPACHER, CLAUDIO R.; GRANADOS, ALEJANDRO M.
Revista:
Molecular Catalysis
Editorial:
Elsevier
Referencias:
Año: 2020 vol. 493
ISSN:
2468-8231
Resumen:
The α-amination reaction of ketones was studied and the reaction conditions were analysed by green metrics.Propiophenone and two aliphatic ketones, saturated cyclic and acyclic secondary amines were used, carbohydrateCu2+ complexes were the catalysts to obtain the brominate intermediates. Traditional stirring and ultrasoundmethods were compared. The use of α-CDCuBr2 complex in the presence of propiophenone, morpholineand O2 was the best condition to carry out the α-amination reaction using a One Pot synthesis, with an 80 %yield of product isolated and no by-product was detected.
