Novel genetic loci affecting facial shape variation in humans

XIONG, ZIYI; DANKOVA, GABRIELA; HOWE, LAURENCE J.; LEE, MYOUNG KEUN; HYSI, PIRRO G.; DE JONG, MARKUS A.; ZHU, GU; ADHIKAR, KAUSTUBH; LI, DAN; LI, YI; PAN, BO; FEINGOLD, ELEANOR; MARAZITA, MARY L.; SHAFFER, JOHN R.; MCALONEY, KERRIE; XU, SHUHUA; JIN, LI; WANG, SIJIA; DE VRI, FEMKE M.; LENDEMEIJE, BAS; RICHMOND, STEPHEN; ZHUROV, ALEXEI; LEWIS, SARAH; SHARP, GEMMA; PATERNOSTER, LAVINIA; THOMPSON, HOLLY; GONZALEZ-JOSE, ROLANDO; CATIRA BORTOLINI, MARIA; CANIZALES-QUINTEROS, SAMUEL; GALLO, CARLA; POLETTI, GIOVANNI; BEDOYA, GABRIEL; ROTHHAMMER, FRANCISCO; UITTERLINDEN, ANDRÉ G.; IKRAM, M. ARFAN; WOLVIUS, EPPO B.; KUSHNER, STEVEN A.; NIJSTEN, TAMAR; PALSTRA, ROBERT-JAN; BOEHRINGER, STEFAN; MEDLAND, SARAH E.; TANG, KUN; RUIZ-LINARES, ANDRÉS; MARTIN, NICHOLAS G.; SPECTOR, TIMOTHY D.; STERGIAKOULI, EVIE; WEINBERG, SETH M.; LIU, FAN; KAYSER, MANFRED

eLife

eLife Sciences Publications Ltd

Año: 2019 vol. 8

The human face represents a combined set of highly heritable phenotypes, but knowledge on its genetic architecture remains limited, despite the relevance for various fields. A series of genome wide association studies on 78 facial shape phenotypes quantified from 3-dimensional facial images of 10,115 Europeans identified 24 genetic loci reaching study-wide suggestive association (p