INVESTIGADORES
GONZALEZ CID Marcela Beatriz
artículos
Título:
Chromosome damage induced by carboplatin (CBDCA)
Autor/es:
GONZALEZ CID M, MUDRY M, LARRIPA I
Revista:
TOXICOLOGY LETTERS
Editorial:
ELSEVIER IRELAND LTD
Referencias:
Lugar: Amsterdam; Año: 1995 vol. 76 p. 97 - 103
ISSN:
0378-4274
Resumen:
The chromosome damage induced by carboplatin (CBDCA) was evaluated in vitro. In human lymphocytes 5 ìg/ml CBDCA produced a 7-fold increase in the frequency of sister chromatid exchanges (SCE) and a 3-fold increase in the number of cells with structural abnormalities compared with the control. Likewise, at this highest dose a significant increase was induced in the value of micronuclei (MN) and an important delay in the lymphocyte cycle progression was observed. In Chinese hamster ovary (CHO) cells, CBDCA showed a significant increase in chromosome aberrations (CA) at the doses assayed. The increase of SCE, CA and MN by CBDCA remained much lower than that produced by mitomycin C (positive control). The results suggest that CBDCA is a DNA-damaging drug with similar behaviour as an alkylating agent.
