Thermal behaviour, biological activity and conformational study of a [methoprene / ß-cyclodextrin] complex in a smoke generating formulation

P. GONZÁLEZ AUDINO, H. MASUH AND E. ZERBA

MOLECULES

MOLECULAR DIVERSITY PRESERVATION INTERNATIONAL-MDPI

Año: 2005 vol. 10 p. 534 - 544

1420-3049

Abstract: Methoprene, an insect growth regulator, was complexed with ß-cyclodextrin, yielding a stable inclusion complex. TGA, X-ray powder diffraction and conformational analysis have been used to confirm the inclusion complex. The interaction between methoprene and ß-cyclodextrin was investigated by means of Molecular Mechanics. The results account for the formation of an 1:1 inclusion complex stabilised by Van der Waals forces and hydrogen bonds. The [ß-cyclodextrin –methoprene] complex included in smoke generating formulations and protected from thermal decomposition by the foaming agent (azodicarbonamide) showed to be stable enough to release methoprene in fumes with good yields. The improved stabilty of methoprene complex showed a correlation in increased biological activity against Musca domestica.