INVESTIGADORES
GOMEZ Karina Andrea
congresos y reuniones científicas
Título:
Detection of specific IgE antibodies against Trypanosoma cruzi arginine kinase
Autor/es:
VALERA, EDWARD; GOMEZ, KARINA A; REIGADA, CHANTAL; SAYE, MELISA; DIGIROLAMO, FABIO; PEREIRA, CLAUDIO; MIRANDA, MARIANA
Lugar:
Buenos Aires
Reunión:
Congreso; I Reunión Conjunta de Sociedades de Biociencias; 2017
Institución organizadora:
Sociedad Argentina de Protozoologia y Enfermedades Parasitarias (SAP)
Resumen:
The krginine kinase from Trypanosoma cruzi (TcAK) is thought to be the product of gene transfer from an invertebrate host to a Trypanosoma ancestor. The function of this enzyme in the parasite is still unknown, but since it was found in extra-cellular T. cruzi vesicles, and it shares a very conserved sequence with invertebrate AKs, which are well known allergens in a very wide range of species, we suspect that TcAK might have some immune modulating action by making immune response incline towards a Th2 response that is ineffective against the parasite, instead of a Th1 response that could control the infection.
