INVESTIGADORES
GIOVAMBATTISTA Andres
artículos
Título:
Neuroendocrine, Metabolic, and Immune Functions during the Acute Phase Response of InflammatoryStress in Monosodium L-Glutamate-Damaged,Hyperadipose Male Rat
Autor/es:
CASTROGIOVANNI, DANIEL; GAILLARD, ROLF; GIOVAMBATTISTA , ANDRÉS; SPINEDI, EDUARDO
Revista:
NEUROENDOCRINOLOGY
Editorial:
KARGER
Referencias:
Lugar: Suiza; Año: 2008 vol. 88 p. 227 - 234
ISSN:
0028-3835
Resumen:
In rats, neonatal treatment with monosodium L-glutamate
(MSG) induces several metabolic and neuroendocrine abnormalities,
which result in hyperadiposity. No data exist,
however, regarding neuroendocrine, immune and metabolic
responses to acute endotoxemia in the MSG-damaged rat.
We studied the consequences of MSG treatment during the
acute phase response of inflammatory stress. Neonatal male
rats were treated with MSG or vehicle (controls, CTR) and
studied at age 90 days. Pituitary, adrenal, adipo-insular axis,
immune, metabolic and gonadal functions were explored
before and up to 5 h after single sub-lethal i.p. injection of
bacterial lipopolysaccharide (LPS; 150 g/kg). Our results
showed that, during the acute phase response of inflammatory
stress in MSG rats: (1) the corticotrope-adrenal, leptin,
insulin and triglyceride responses were higher than in CTR
rats, (2) pro-inflammatory (TNF ) cytokine response was impaired
and anti-inflammatory (IL-10) cytokine response was
normal, and (3) changes in peripheral estradiol and testosterone
levels after LPS varied as in CTR rats. These data indicate
that metabolic and neroendocrine-immune functions
are altered in MSG-damaged rats. Our study also suggests
that the enhanced corticotrope-corticoadrenal activity in
MSG animals could be responsible, at least in part, for the
immune and metabolic derangements characterizing hypothalamic obesity.
that the enhanced corticotrope-corticoadrenal activity in
MSG animals could be responsible, at least in part, for the
immune and metabolic derangements characterizing hypothalamic obesity.
that the enhanced corticotrope-corticoadrenal activity in
MSG animals could be responsible, at least in part, for the
immune and metabolic derangements characterizing hypothalamic obesity.
and anti-inflammatory (IL-10) cytokine response was
normal, and (3) changes in peripheral estradiol and testosterone
levels after LPS varied as in CTR rats. These data indicate
that metabolic and neroendocrine-immune functions
are altered in MSG-damaged rats. Our study also suggests
that the enhanced corticotrope-corticoadrenal activity in
MSG animals could be responsible, at least in part, for the
immune and metabolic derangements characterizing hypothalamic obesity.
that the enhanced corticotrope-corticoadrenal activity in
MSG animals could be responsible, at least in part, for the
immune and metabolic derangements characterizing hypothalamic obesity.
that the enhanced corticotrope-corticoadrenal activity in
MSG animals could be responsible, at least in part, for the
immune and metabolic derangements characterizing hypothalamic obesity.
showed that, during the acute phase response of inflammatory
stress in MSG rats: (1) the corticotrope-adrenal, leptin,
insulin and triglyceride responses were higher than in CTR
rats, (2) pro-inflammatory (TNF ) cytokine response was impaired
and anti-inflammatory (IL-10) cytokine response was
normal, and (3) changes in peripheral estradiol and testosterone
levels after LPS varied as in CTR rats. These data indicate
that metabolic and neroendocrine-immune functions
are altered in MSG-damaged rats. Our study also suggests
that the enhanced corticotrope-corticoadrenal activity in
MSG animals could be responsible, at least in part, for the
immune and metabolic derangements characterizing hypothalamic obesity.
that the enhanced corticotrope-corticoadrenal activity in
MSG animals could be responsible, at least in part, for the
immune and metabolic derangements characterizing hypothalamic obesity.
that the enhanced corticotrope-corticoadrenal activity in
MSG animals could be responsible, at least in part, for the
immune and metabolic derangements characterizing hypothalamic obesity.
and anti-inflammatory (IL-10) cytokine response was
normal, and (3) changes in peripheral estradiol and testosterone
levels after LPS varied as in CTR rats. These data indicate
that metabolic and neroendocrine-immune functions
are altered in MSG-damaged rats. Our study also suggests
that the enhanced corticotrope-corticoadrenal activity in
MSG animals could be responsible, at least in part, for the
immune and metabolic derangements characterizing hypothalamic obesity.
that the enhanced corticotrope-corticoadrenal activity in
MSG animals could be responsible, at least in part, for the
immune and metabolic derangements characterizing hypothalamic obesity.
that the enhanced corticotrope-corticoadrenal activity in
MSG animals could be responsible, at least in part, for the
immune and metabolic derangements characterizing hypothalamic obesity.
(MSG) induces several metabolic and neuroendocrine abnormalities,
which result in hyperadiposity. No data exist,
however, regarding neuroendocrine, immune and metabolic
responses to acute endotoxemia in the MSG-damaged rat.
We studied the consequences of MSG treatment during the
acute phase response of inflammatory stress. Neonatal male
rats were treated with MSG or vehicle (controls, CTR) and
studied at age 90 days. Pituitary, adrenal, adipo-insular axis,
immune, metabolic and gonadal functions were explored
before and up to 5 h after single sub-lethal i.p. injection of
bacterial lipopolysaccharide (LPS; 150 g/kg). Our results
showed that, during the acute phase response of inflammatory
stress in MSG rats: (1) the corticotrope-adrenal, leptin,
insulin and triglyceride responses were higher than in CTR
rats, (2) pro-inflammatory (TNF ) cytokine response was impaired
and anti-inflammatory (IL-10) cytokine response was
normal, and (3) changes in peripheral estradiol and testosterone
levels after LPS varied as in CTR rats. These data indicate
that metabolic and neroendocrine-immune functions
are altered in MSG-damaged rats. Our study also suggests
that the enhanced corticotrope-corticoadrenal activity in
MSG animals could be responsible, at least in part, for the
immune and metabolic derangements characterizing hypothalamic obesity.
that the enhanced corticotrope-corticoadrenal activity in
MSG animals could be responsible, at least in part, for the
immune and metabolic derangements characterizing hypothalamic obesity.
that the enhanced corticotrope-corticoadrenal activity in
MSG animals could be responsible, at least in part, for the
immune and metabolic derangements characterizing hypothalamic obesity.
and anti-inflammatory (IL-10) cytokine response was
normal, and (3) changes in peripheral estradiol and testosterone
levels after LPS varied as in CTR rats. These data indicate
that metabolic and neroendocrine-immune functions
are altered in MSG-damaged rats. Our study also suggests
that the enhanced corticotrope-corticoadrenal activity in
MSG animals could be responsible, at least in part, for the
immune and metabolic derangements characterizing hypothalamic obesity.
that the enhanced corticotrope-corticoadrenal activity in
MSG animals could be responsible, at least in part, for the
immune and metabolic derangements characterizing hypothalamic obesity.
that the enhanced corticotrope-corticoadrenal activity in
MSG animals could be responsible, at least in part, for the
immune and metabolic derangements characterizing hypothalamic obesity.
showed that, during the acute phase response of inflammatory
stress in MSG rats: (1) the corticotrope-adrenal, leptin,
insulin and triglyceride responses were higher than in CTR
rats, (2) pro-inflammatory (TNF ) cytokine response was impaired
and anti-inflammatory (IL-10) cytokine response was
normal, and (3) changes in peripheral estradiol and testosterone
levels after LPS varied as in CTR rats. These data indicate
that metabolic and neroendocrine-immune functions
are altered in MSG-damaged rats. Our study also suggests
that the enhanced corticotrope-corticoadrenal activity in
MSG animals could be responsible, at least in part, for the
immune and metabolic derangements characterizing hypothalamic obesity.
that the enhanced corticotrope-corticoadrenal activity in
MSG animals could be responsible, at least in part, for the
immune and metabolic derangements characterizing hypothalamic obesity.
that the enhanced corticotrope-corticoadrenal activity in
MSG animals could be responsible, at least in part, for the
immune and metabolic derangements characterizing hypothalamic obesity.
and anti-inflammatory (IL-10) cytokine response was
normal, and (3) changes in peripheral estradiol and testosterone
levels after LPS varied as in CTR rats. These data indicate
that metabolic and neroendocrine-immune functions
are altered in MSG-damaged rats. Our study also suggests
that the enhanced corticotrope-corticoadrenal activity in
MSG animals could be responsible, at least in part, for the
immune and metabolic derangements characterizing hypothalamic obesity.
that the enhanced corticotrope-corticoadrenal activity in
MSG animals could be responsible, at least in part, for the
immune and metabolic derangements characterizing hypothalamic obesity.
that the enhanced corticotrope-corticoadrenal activity in
MSG animals could be responsible, at least in part, for the
immune and metabolic derangements characterizing hypothalamic obesity.
L-glutamate
(MSG) induces several metabolic and neuroendocrine abnormalities,
which result in hyperadiposity. No data exist,
however, regarding neuroendocrine, immune and metabolic
responses to acute endotoxemia in the MSG-damaged rat.
We studied the consequences of MSG treatment during the
acute phase response of inflammatory stress. Neonatal male
rats were treated with MSG or vehicle (controls, CTR) and
studied at age 90 days. Pituitary, adrenal, adipo-insular axis,
immune, metabolic and gonadal functions were explored
before and up to 5 h after single sub-lethal i.p. injection of
bacterial lipopolysaccharide (LPS; 150 g/kg). Our results
showed that, during the acute phase response of inflammatory
stress in MSG rats: (1) the corticotrope-adrenal, leptin,
insulin and triglyceride responses were higher than in CTR
rats, (2) pro-inflammatory (TNF ) cytokine response was impaired
and anti-inflammatory (IL-10) cytokine response was
normal, and (3) changes in peripheral estradiol and testosterone
levels after LPS varied as in CTR rats. These data indicate
that metabolic and neroendocrine-immune functions
are altered in MSG-damaged rats. Our study also suggests
that the enhanced corticotrope-corticoadrenal activity in
MSG animals could be responsible, at least in part, for the
immune and metabolic derangements characterizing hypothalamic obesity.
that the enhanced corticotrope-corticoadrenal activity in
MSG animals could be responsible, at least in part, for the
immune and metabolic derangements characterizing hypothalamic obesity.
that the enhanced corticotrope-corticoadrenal activity in
MSG animals could be responsible, at least in part, for the
immune and metabolic derangements characterizing hypothalamic obesity.
and anti-inflammatory (IL-10) cytokine response was
normal, and (3) changes in peripheral estradiol and testosterone
levels after LPS varied as in CTR rats. These data indicate
that metabolic and neroendocrine-immune functions
are altered in MSG-damaged rats. Our study also suggests
that the enhanced corticotrope-corticoadrenal activity in
MSG animals could be responsible, at least in part, for the
immune and metabolic derangements characterizing hypothalamic obesity.
that the enhanced corticotrope-corticoadrenal activity in
MSG animals could be responsible, at least in part, for the
immune and metabolic derangements characterizing hypothalamic obesity.
that the enhanced corticotrope-corticoadrenal activity in
MSG animals could be responsible, at least in part, for the
immune and metabolic derangements characterizing hypothalamic obesity.
showed that, during the acute phase response of inflammatory
stress in MSG rats: (1) the corticotrope-adrenal, leptin,
insulin and triglyceride responses were higher than in CTR
rats, (2) pro-inflammatory (TNF ) cytokine response was impaired
and anti-inflammatory (IL-10) cytokine response was
normal, and (3) changes in peripheral estradiol and testosterone
levels after LPS varied as in CTR rats. These data indicate
that metabolic and neroendocrine-immune functions
are altered in MSG-damaged rats. Our study also suggests
that the enhanced corticotrope-corticoadrenal activity in
MSG animals could be responsible, at least in part, for the
immune and metabolic derangements characterizing hypothalamic obesity.
that the enhanced corticotrope-corticoadrenal activity in
MSG animals could be responsible, at least in part, for the
immune and metabolic derangements characterizing hypothalamic obesity.
that the enhanced corticotrope-corticoadrenal activity in
MSG animals could be responsible, at least in part, for the
immune and metabolic derangements characterizing hypothalamic obesity.
and anti-inflammatory (IL-10) cytokine response was
normal, and (3) changes in peripheral estradiol and testosterone
levels after LPS varied as in CTR rats. These data indicate
that metabolic and neroendocrine-immune functions
are altered in MSG-damaged rats. Our study also suggests
that the enhanced corticotrope-corticoadrenal activity in
MSG animals could be responsible, at least in part, for the
immune and metabolic derangements characterizing hypothalamic obesity.
that the enhanced corticotrope-corticoadrenal activity in
MSG animals could be responsible, at least in part, for the
immune and metabolic derangements characterizing hypothalamic obesity.
that the enhanced corticotrope-corticoadrenal activity in
MSG animals could be responsible, at least in part, for the
immune and metabolic derangements characterizing hypothalamic obesity.
g/kg). Our results
showed that, during the acute phase response of inflammatory
stress in MSG rats: (1) the corticotrope-adrenal, leptin,
insulin and triglyceride responses were higher than in CTR
rats, (2) pro-inflammatory (TNF ) cytokine response was impaired
and anti-inflammatory (IL-10) cytokine response was
normal, and (3) changes in peripheral estradiol and testosterone
levels after LPS varied as in CTR rats. These data indicate
that metabolic and neroendocrine-immune functions
are altered in MSG-damaged rats. Our study also suggests
that the enhanced corticotrope-corticoadrenal activity in
MSG animals could be responsible, at least in part, for the
immune and metabolic derangements characterizing hypothalamic obesity.
that the enhanced corticotrope-corticoadrenal activity in
MSG animals could be responsible, at least in part, for the
immune and metabolic derangements characterizing hypothalamic obesity.
that the enhanced corticotrope-corticoadrenal activity in
MSG animals could be responsible, at least in part, for the
immune and metabolic derangements characterizing hypothalamic obesity.
and anti-inflammatory (IL-10) cytokine response was
normal, and (3) changes in peripheral estradiol and testosterone
levels after LPS varied as in CTR rats. These data indicate
that metabolic and neroendocrine-immune functions
are altered in MSG-damaged rats. Our study also suggests
that the enhanced corticotrope-corticoadrenal activity in
MSG animals could be responsible, at least in part, for the
immune and metabolic derangements characterizing hypothalamic obesity.
that the enhanced corticotrope-corticoadrenal activity in
MSG animals could be responsible, at least in part, for the
immune and metabolic derangements characterizing hypothalamic obesity.
that the enhanced corticotrope-corticoadrenal activity in
MSG animals could be responsible, at least in part, for the
immune and metabolic derangements characterizing hypothalamic obesity.
) cytokine response was impaired
and anti-inflammatory (IL-10) cytokine response was
normal, and (3) changes in peripheral estradiol and testosterone
levels after LPS varied as in CTR rats. These data indicate
that metabolic and neroendocrine-immune functions
are altered in MSG-damaged rats. Our study also suggests
that the enhanced corticotrope-corticoadrenal activity in
MSG animals could be responsible, at least in part, for the
immune and metabolic derangements characterizing hypothalamic obesity.
that the enhanced corticotrope-corticoadrenal activity in
MSG animals could be responsible, at least in part, for the
immune and metabolic derangements characterizing hypothalamic obesity.
that the enhanced corticotrope-corticoadrenal activity in
MSG animals could be responsible, at least in part, for the
immune and metabolic derangements characterizing hypothalamic obesity.