INVESTIGADORES
GIOVAMBATTISTA Andres
artículos
Título:
TESTIS STRUCTURE AND FUNCTION IN A NON-GENETIC HYPERADIPOSE
Autor/es:
FRANCA, LR; SUESCUN, MO; MIRANDA, JR; GIOVAMBATTISTA, A; PERELLO, M; SPINEDI, E; CALANDRA, RS
Revista:
ENDOCRINOLOGY
Editorial:
Endocrine Society
Referencias:
Lugar: United States; Año: 2006 vol. 147 p. 1556 - 1563
ISSN:
0013-7227
Resumen:
Abstract
There are few data for hormonal levels and testis structure and function during postnatal
development in rats neonatally-treated with monosodium L-glutamate (MSG). In our study,
newborn male pups were i.p. injected with MSG (4 mg/g BW) every 2 days up to 10d of age,
and investigated at prepubertal and adult ages. Plasma levels of leptin, LH, FSH, prolactin, T,
corticosterone and free thyroxin (FT4) were measured. MSG-rats displayed elevated
circulating levels of corticosterone and hyperadiposity/hyperleptinemia, regardless of the age
examined; conversely, circulating prolactin levels were not affected. Moreover, prepubertal
MSG-rats revealed a significant (p<0.05) reduction in testis weight and the number of Sertoli
(SC) and Leydig (LC) cells per testis. Leptin plasma levels were several-fold higher (2.41 vs.
8.07; p<0.05) in prepubertal MSG rats, and these animals displayed plasma LH, FSH, T and
FT4 levels significantly (p<0.05) decreased. Taken together, these data indicate that testis
development, as well as SC and LC proliferation, were disturbed in prepubertal MSG-rats.
Adult MSG-rats also displayed significantly higher leptin plasma levels (7.26 vs. 27.04;
p<0.05) and lower (p<0.05) LH and FSH plasma levels. However, T and FT4 plasma levels
were normal, and no apparent alterations were observed in testis structure of MSG-rats. Only
the number of SC per testis was significantly (p<0.05) reduced in the adult MSG-rats. In
conclusion, although early installed hyperadipose/hyperleptinemia phenotype was probably
responsible for the reproductive axis damages in MSG animals, it remains to be investigated
whether this condition is the main factor for HPG axis dysfunction in MSG-rats.
were normal, and no apparent alterations were observed in testis structure of MSG-rats. Only
the number of SC per testis was significantly (p<0.05) reduced in the adult MSG-rats. In
conclusion, although early installed hyperadipose/hyperleptinemia phenotype was probably
responsible for the reproductive axis damages in MSG animals, it remains to be investigated
whether this condition is the main factor for HPG axis dysfunction in MSG-rats.
development, as well as SC and LC proliferation, were disturbed in prepubertal MSG-rats.
Adult MSG-rats also displayed significantly higher leptin plasma levels (7.26 vs. 27.04;
p<0.05) and lower (p<0.05) LH and FSH plasma levels. However, T and FT4 plasma levels
were normal, and no apparent alterations were observed in testis structure of MSG-rats. Only
the number of SC per testis was significantly (p<0.05) reduced in the adult MSG-rats. In
conclusion, although early installed hyperadipose/hyperleptinemia phenotype was probably
responsible for the reproductive axis damages in MSG animals, it remains to be investigated
whether this condition is the main factor for HPG axis dysfunction in MSG-rats.
were normal, and no apparent alterations were observed in testis structure of MSG-rats. Only
the number of SC per testis was significantly (p<0.05) reduced in the adult MSG-rats. In
conclusion, although early installed hyperadipose/hyperleptinemia phenotype was probably
responsible for the reproductive axis damages in MSG animals, it remains to be investigated
whether this condition is the main factor for HPG axis dysfunction in MSG-rats.
circulating levels of corticosterone and hyperadiposity/hyperleptinemia, regardless of the age
examined; conversely, circulating prolactin levels were not affected. Moreover, prepubertal
MSG-rats revealed a significant (p<0.05) reduction in testis weight and the number of Sertoli
(SC) and Leydig (LC) cells per testis. Leptin plasma levels were several-fold higher (2.41 vs.
8.07; p<0.05) in prepubertal MSG rats, and these animals displayed plasma LH, FSH, T and
FT4 levels significantly (p<0.05) decreased. Taken together, these data indicate that testis
development, as well as SC and LC proliferation, were disturbed in prepubertal MSG-rats.
Adult MSG-rats also displayed significantly higher leptin plasma levels (7.26 vs. 27.04;
p<0.05) and lower (p<0.05) LH and FSH plasma levels. However, T and FT4 plasma levels
were normal, and no apparent alterations were observed in testis structure of MSG-rats. Only
the number of SC per testis was significantly (p<0.05) reduced in the adult MSG-rats. In
conclusion, although early installed hyperadipose/hyperleptinemia phenotype was probably
responsible for the reproductive axis damages in MSG animals, it remains to be investigated
whether this condition is the main factor for HPG axis dysfunction in MSG-rats.
were normal, and no apparent alterations were observed in testis structure of MSG-rats. Only
the number of SC per testis was significantly (p<0.05) reduced in the adult MSG-rats. In
conclusion, although early installed hyperadipose/hyperleptinemia phenotype was probably
responsible for the reproductive axis damages in MSG animals, it remains to be investigated
whether this condition is the main factor for HPG axis dysfunction in MSG-rats.
development, as well as SC and LC proliferation, were disturbed in prepubertal MSG-rats.
Adult MSG-rats also displayed significantly higher leptin plasma levels (7.26 vs. 27.04;
p<0.05) and lower (p<0.05) LH and FSH plasma levels. However, T and FT4 plasma levels
were normal, and no apparent alterations were observed in testis structure of MSG-rats. Only
the number of SC per testis was significantly (p<0.05) reduced in the adult MSG-rats. In
conclusion, although early installed hyperadipose/hyperleptinemia phenotype was probably
responsible for the reproductive axis damages in MSG animals, it remains to be investigated
whether this condition is the main factor for HPG axis dysfunction in MSG-rats.
were normal, and no apparent alterations were observed in testis structure of MSG-rats. Only
the number of SC per testis was significantly (p<0.05) reduced in the adult MSG-rats. In
conclusion, although early installed hyperadipose/hyperleptinemia phenotype was probably
responsible for the reproductive axis damages in MSG animals, it remains to be investigated
whether this condition is the main factor for HPG axis dysfunction in MSG-rats.
4) were measured. MSG-rats displayed elevated
circulating levels of corticosterone and hyperadiposity/hyperleptinemia, regardless of the age
examined; conversely, circulating prolactin levels were not affected. Moreover, prepubertal
MSG-rats revealed a significant (p<0.05) reduction in testis weight and the number of Sertoli
(SC) and Leydig (LC) cells per testis. Leptin plasma levels were several-fold higher (2.41 vs.
8.07; p<0.05) in prepubertal MSG rats, and these animals displayed plasma LH, FSH, T and
FT4 levels significantly (p<0.05) decreased. Taken together, these data indicate that testis
development, as well as SC and LC proliferation, were disturbed in prepubertal MSG-rats.
Adult MSG-rats also displayed significantly higher leptin plasma levels (7.26 vs. 27.04;
p<0.05) and lower (p<0.05) LH and FSH plasma levels. However, T and FT4 plasma levels
were normal, and no apparent alterations were observed in testis structure of MSG-rats. Only
the number of SC per testis was significantly (p<0.05) reduced in the adult MSG-rats. In
conclusion, although early installed hyperadipose/hyperleptinemia phenotype was probably
responsible for the reproductive axis damages in MSG animals, it remains to be investigated
whether this condition is the main factor for HPG axis dysfunction in MSG-rats.
were normal, and no apparent alterations were observed in testis structure of MSG-rats. Only
the number of SC per testis was significantly (p<0.05) reduced in the adult MSG-rats. In
conclusion, although early installed hyperadipose/hyperleptinemia phenotype was probably
responsible for the reproductive axis damages in MSG animals, it remains to be investigated
whether this condition is the main factor for HPG axis dysfunction in MSG-rats.
development, as well as SC and LC proliferation, were disturbed in prepubertal MSG-rats.
Adult MSG-rats also displayed significantly higher leptin plasma levels (7.26 vs. 27.04;
p<0.05) and lower (p<0.05) LH and FSH plasma levels. However, T and FT4 plasma levels
were normal, and no apparent alterations were observed in testis structure of MSG-rats. Only
the number of SC per testis was significantly (p<0.05) reduced in the adult MSG-rats. In
conclusion, although early installed hyperadipose/hyperleptinemia phenotype was probably
responsible for the reproductive axis damages in MSG animals, it remains to be investigated
whether this condition is the main factor for HPG axis dysfunction in MSG-rats.
were normal, and no apparent alterations were observed in testis structure of MSG-rats. Only
the number of SC per testis was significantly (p<0.05) reduced in the adult MSG-rats. In
conclusion, although early installed hyperadipose/hyperleptinemia phenotype was probably
responsible for the reproductive axis damages in MSG animals, it remains to be investigated
whether this condition is the main factor for HPG axis dysfunction in MSG-rats.
4 levels significantly (p<0.05) decreased. Taken together, these data indicate that testis
development, as well as SC and LC proliferation, were disturbed in prepubertal MSG-rats.
Adult MSG-rats also displayed significantly higher leptin plasma levels (7.26 vs. 27.04;
p<0.05) and lower (p<0.05) LH and FSH plasma levels. However, T and FT4 plasma levels
were normal, and no apparent alterations were observed in testis structure of MSG-rats. Only
the number of SC per testis was significantly (p<0.05) reduced in the adult MSG-rats. In
conclusion, although early installed hyperadipose/hyperleptinemia phenotype was probably
responsible for the reproductive axis damages in MSG animals, it remains to be investigated
whether this condition is the main factor for HPG axis dysfunction in MSG-rats.
were normal, and no apparent alterations were observed in testis structure of MSG-rats. Only
the number of SC per testis was significantly (p<0.05) reduced in the adult MSG-rats. In
conclusion, although early installed hyperadipose/hyperleptinemia phenotype was probably
responsible for the reproductive axis damages in MSG animals, it remains to be investigated
whether this condition is the main factor for HPG axis dysfunction in MSG-rats.
4 plasma levels
were normal, and no apparent alterations were observed in testis structure of MSG-rats. Only
the number of SC per testis was significantly (p<0.05) reduced in the adult MSG-rats. In
conclusion, although early installed hyperadipose/hyperleptinemia phenotype was probably
responsible for the reproductive axis damages in MSG animals, it remains to be investigated
whether this condition is the main factor for HPG axis dysfunction in MSG-rats.