INVESTIGADORES
GENARO Ana Maria
artículos
Título:
Niacin Modulates Pro-inflammatory Cytokine Secretion. A Potential Mechanism Involved in its Anti-atherosclerotic Effect.
Autor/es:
PEDRO SAUL LIPSZYC; GRACIELA A CREMACHI; MARÍA A ZORRILLA ZUBILETE; MARÍA LAURA AÓN BERTOLINO; FRANCISCO CAPANI; ANA MARÍA GENARO
Revista:
The open cardiovascular medicine journal
Editorial:
Bentham Science Publishers
Referencias:
Año: 2013 vol. 7 p. 90 - 98
ISSN:
1874-1924
Resumen:
The pathogenesis of atherosclerosis includes the assignment of a
critical role to cells of the monocyte/macrophage lineage and to
pro-inflammatory cytokines. Niacin is known to improve lipid metabolism
and to produce beneficial modification of cardiovascular risk factors.
The aim of this work was to investigate if Niacin is able to modulate
pro-inflammatory cytokine production in macrophages in a murine model
of atherosclerosis. For this purpose C57Bl/6J mice fed with
atherogenic diet (AGD) or with conventional chow diet were used. The
AGD group showed an increase in body weight and in total plasma
cholesterol, with no differences in triglyceride or HDL levels.
Lesions in arterial walls were observed. The characterization of
Niacin receptor showed an increase in the receptor number of
macrophages from the AGD group. Macrophages from control and AGD
animals treated in vitro with an inflammatory stimulus showed elevated
levels of IL-6, IL-1 and TNF-α, that were even higher in macrophages
from AGD mice. Niacin was able to decrease the production of
pro-inflammatory cytokines in stimulated macrophages. Similar effect
of Niacin was observed in an in vivo model of inflammation. These
results show an attenuating inflammatory mechanism for this
therapeutic agent and would point out its potential action in plaque
stabilization and in the prevention of atherosclerosis progression.
Furthermore, the present results provide the basis for future studies
on the potential contribution of Niacin to anti-inflammatory
therapies.