Haloperidol Effect on Intracellular Signals System Coupled to a -Adrenergic Receptor in 1 Rat Cerebral Frontal Cortex

TANIA BORDA; GRACIELA A CREMASCHI; ANA MARÍA GENARO

CELLULAR SIGNALLING

ELSEVIER SCIENCE INC

Lugar: Oxford; Año: 1999 vol. 11 p. 293 - 300

0898-6568

The induction of intracellular signals coupled to a1-adrenoceptor by haloperidol, were studied in rat cerebral frontal cortex. The neuroleptic exerts a biphasic effect on nitric oxide synthase NOS, inhibiting the enzymatic activity at low concentrations 10y9 M., while higher concentrations 10y5 M. increased it. Protein kinase C PKC. and phosphoinositol turnover PIs. were involved in these actions, ashaloperidol induced PKC translocation at low concentrations, and increased PIs turnover at high concentrations. All the effects of haloperidol were blocked by the a1-adrenoceptor antagonist prazosin and the phospholipase C PLC. inhibitor NCDC. The possibility that a cross-talk between both enzymatic pathways depending on the neuroleptic concentration used in rat cerebral frontal cortex, is also discussed.